Manuela Olmedo-Córdoba, José Juan León, Álvaro López-Villegas, Elena Martín-González, Margarita Moreno-Montoya
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引用次数: 0
Abstract
Rationale: Compulsivity is increasingly recognized as a transdiagnostic trait that amplifies vulnerability to alcohol use disorders. However, its specific role in shaping social behavior and decision-making remains underexplored.
Objective: This study aimed to identify a vulnerable phenotype characterized by compulsive alcohol drinking and evaluate its behavioral alterations within the social behavior and cognitive processes domains of the Research Domain Criteria (RDoC), considering sex as a modulatory factor.
Methods: Male and female Wistar rats were exposed to Schedule-Induced Polydipsia (SIP), first with water and then with alcohol. Distinct groups were formed based on intake patterns following a cluster-based analysis. We then assessed social subordination with the social dominance tube test (SDTT), sociability and social novelty with the three-chambered Crawley's test (3CT), and decision-making with the rodent Gambling Task (rGT).
Results: We identified four distinct behavioral profiles: Low Compulsive, Compulsive Alcohol, Compulsive Water, and High Compulsive. This segmentation revealed sex-specific distributions: males were overrepresented in high alcohol consumption clusters, while females were more prevalent in low-consumption profiles, indicating sex-related susceptibility. The High Compulsive phenotype diverged from the Compulsive Alcohol group, showing lower hierarchical status and a less risky decision-making strategy, whereas no significant differences were found in overall social interaction between groups. However, general alcohol consumption diminished general sociability and abolished sex differences, suggesting a disruption of innate social motivation.
Conclusions: These findings support that the combination of compulsivity and alcohol intake increases behavioral vulnerability, specifically in domains of social competence and decision-making.
期刊介绍：
Official Journal of the European Behavioural Pharmacology Society (EBPS)
Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields:
Human Psychopharmacology: Experimental
This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered.
Human Psychopharmacology: Clinical and Translational
This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects.
Preclinical psychopharmacology: Behavioral and Neural
This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels.
Preclinical Psychopharmacology: Translational
This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways.
Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic
This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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