Exploring the Causal Association Between Oral Microbiome Abundance and Asthma Risk Using Two-Sample Mendelian Randomization.

IF 2.3 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-09-01 DOI:10.1002/ppul.71301

Huagui Han, Lingwen Zhang, Yawei Wu, Qiuyun Ye, Xingjun Cai

{"title":"Exploring the Causal Association Between Oral Microbiome Abundance and Asthma Risk Using Two-Sample Mendelian Randomization.","authors":"Huagui Han, Lingwen Zhang, Yawei Wu, Qiuyun Ye, Xingjun Cai","doi":"10.1002/ppul.71301","DOIUrl":null,"url":null,"abstract":"Background: Asthma is influenced by genetic and environmental factors, and emerging evidence suggests that the oral microbiome may play a role in its pathogenesis. This study aimed to explore the causal association between oral microbiome abundance and asthma risk using a two-sample Mendelian randomization (MR) approach.Methods: We utilized genome-wide association studies (GWAS) data comprising 56,167 asthma cases and 408,442 controls of European ancestry, alongside 610 individuals from the Danish ADDITION-PRO cohort for oral microbiome analysis. We selected 267 single nucleotide polymorphisms (SNPs) linked to salivary microbiota as instrumental variables (IVs) with an F-statistic > 10. MR analyses were carried out using inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods, complemented by sensitivity analyses.Results: Our findings revealed a significant association between specific salivary microbiota and asthma risk. Notably, increased abundance of Genus Rothia was positively associated with asthma risk (IVW: OR = 1.03), while an unspecified Streptococcus species showed a negative correlation (IVW: OR = 0.97). Sensitivity analyses confirmed these results' robustness, with no signs of pleiotropy or significant heterogeneity.Conclusion: The study suggests a causal relationship between specific oral microbiota and asthma risk, emphasizing the oral microbiome's potential significance in asthma pathogenesis.","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 9","pages":"e71301"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ppul.71301","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Asthma is influenced by genetic and environmental factors, and emerging evidence suggests that the oral microbiome may play a role in its pathogenesis. This study aimed to explore the causal association between oral microbiome abundance and asthma risk using a two-sample Mendelian randomization (MR) approach.

Methods: We utilized genome-wide association studies (GWAS) data comprising 56,167 asthma cases and 408,442 controls of European ancestry, alongside 610 individuals from the Danish ADDITION-PRO cohort for oral microbiome analysis. We selected 267 single nucleotide polymorphisms (SNPs) linked to salivary microbiota as instrumental variables (IVs) with an F-statistic > 10. MR analyses were carried out using inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods, complemented by sensitivity analyses.

Results: Our findings revealed a significant association between specific salivary microbiota and asthma risk. Notably, increased abundance of Genus Rothia was positively associated with asthma risk (IVW: OR = 1.03), while an unspecified Streptococcus species showed a negative correlation (IVW: OR = 0.97). Sensitivity analyses confirmed these results' robustness, with no signs of pleiotropy or significant heterogeneity.

Conclusion: The study suggests a causal relationship between specific oral microbiota and asthma risk, emphasizing the oral microbiome's potential significance in asthma pathogenesis.

查看原文本刊更多论文

使用双样本孟德尔随机化方法探索口腔微生物群丰度与哮喘风险之间的因果关系。

背景：哮喘受遗传和环境因素的影响，越来越多的证据表明口腔微生物群可能在其发病机制中发挥作用。本研究旨在通过双样本孟德尔随机化（MR）方法探讨口腔微生物群丰度与哮喘风险之间的因果关系。方法：我们利用全基因组关联研究（GWAS）数据，包括56,167例哮喘病例和408,442名欧洲血统的对照，以及来自丹麦add - pro队列的610名个体进行口腔微生物组分析。我们选择了267个与唾液微生物群相关的单核苷酸多态性（SNPs）作为工具变量（IVs）， f统计量为bb10。磁共振分析采用逆方差加权（IVW）、MR- egger、加权中位数和加权模式方法，辅以敏感性分析。结果：我们的研究结果揭示了特定唾液微生物群与哮喘风险之间的显著关联。值得注意的是，罗氏属的丰度增加与哮喘风险呈正相关（IVW: OR = 1.03），而一种未指定的链球菌呈负相关（IVW: OR = 0.97）。敏感性分析证实了这些结果的稳健性，没有多效性或显著异质性的迹象。结论：本研究提示特定口腔微生物群与哮喘风险之间存在因果关系，强调了口腔微生物群在哮喘发病机制中的潜在意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.