Cortical changes in women with systemic lupus erythematosus with mild cognitive impairment: a voxel-based morphometry and surface-based morphometry study.

IF 3.5 2区 医学 Q1 RHEUMATOLOGY
Minghuang Mo, Yifan Yang, Shuang Liu, Ru Bai, Shu Li, Ruotong Zhao, Xinyu Xu, Yuqi Cheng, Jian Xu
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Abstract

Background: The purpose of this study was to reveal the morphological changes of grey matter (GM) in women systemic lupus erythematosus (wSLE) patients with mild cognitive impairment (MCI) with normal conventional MRI.

Methods: The differences in brain morphological indicators among wSLE with MCI, wSLE without MCI and women healthy control (wHC) group were calculated and compared by voxel-based morphometry and surface-based morphometry. The GM volume (GMV), cortical thickness (CT), indicators of cortical complexity, including fractal dimension (FD), gyration index (GI), sulcus depth, the relationship between brain morphological indicators and clinical features, were analysed.

Results: In comparison to wSLE patients without MCI (n=36), wSLE with MCI (n=26) demonstrated a significant decrease in FD of the left lateral orbitofrontal gyrus. When compared with the wHC group (n=36), both wSLE patients with MCI and wSLE without MCI group exhibited a reduction in GMV in the medial of right superior frontal gyrus, a thinning of CT in the left paracentral and postcentral gyrus as well as in the right pars triangularis gyrus and superior frontal gyrus. Within the wSLE group, Mini-Mental State Examination scores were positively correlated with GMV in the middle of right superior frontal gyrus and with the FD of the left lateral orbitofrontal gyrus.

Conclusion: WSLE patients with MCI have brain morphological changes such as reduced GMV, thinning CT, reduced FD and increased GI. Cortical morphological changes may be involved in the pathological process of MCI in wSLE patients.

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伴有轻度认知障碍的系统性红斑狼疮女性的皮质变化:基于体素的形态测量和基于表面的形态测量研究
背景:本研究的目的是通过正常的常规MRI,揭示女性系统性红斑狼疮(wSLE)伴轻度认知障碍(MCI)患者的灰质(GM)形态学变化。方法:采用基于体素形态学和基于表面形态学的方法,计算比较wSLE合并MCI、非MCI和女性健康对照组(wHC)脑形态学指标的差异。分析脑皮质体积(GMV)、皮质厚度(CT)、皮质复杂性指标分形维数(FD)、旋转指数(GI)、脑沟深度、脑形态学指标与临床特征的关系。结果:与无MCI的wSLE患者(n=36)相比,伴有MCI的wSLE患者(n=26)表现出左侧眶额回外侧FD的显著降低。与wHC组(n=36)相比,合并MCI的wSLE患者和未合并MCI的wSLE患者均表现为右侧额上回内侧GMV减少,左侧中央旁回和中央后回以及右侧三角部回和额上回的CT变薄。在wSLE组中,迷你精神状态检查得分与右侧额上回中部GMV和左侧眶额外侧回FD呈正相关。结论:WSLE合并MCI患者存在GMV降低、CT变薄、FD降低、GI升高等脑形态学改变。皮层形态学改变可能参与了wSLE患者MCI的病理过程。
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来源期刊
Lupus Science & Medicine
Lupus Science & Medicine RHEUMATOLOGY-
CiteScore
5.30
自引率
7.70%
发文量
88
审稿时长
15 weeks
期刊介绍: Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.
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