Transcatheter Ventricular Septal Defect Closure in Children < 10 kg: Anatomical Challenges, and Outcomes with the Konar MFO Device.

IF 1.4 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Utku Pamuk, Hazım Alper Gursu, Emine Azak, İbrahim İlker Çetin
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引用次数: 0

Abstract

This study evaluated the feasibility, safety, and mid-term outcomes of transcatheter ventricular septal defect (VSD) closure using the Konar MFO device in infants weighing < 10 kg, focusing on procedural challenges and anatomical complexities. A retrospective single-center analysis included 34 consecutive patients (mean age: 14.8 months; mean weight: 7.4 kg) who underwent transcatheter VSD closure between January 2022 and December 2024 via transfemoral or transjugular approaches. Technical success was achieved in 94.1% (32/34) of cases. Major complications were rare (5.9%), with no device embolization, arrhythmias, or new-onset valvular regurgitation. The Konar MFO device was successfully deployed across diverse VSD morphologies, including perimembranous, muscular outlet, mid-muscular, and apical-muscular defects, as well as cases with aortic override or multifocal defects requiring dual-device implantation. Procedural challenges, such as papillary muscle knotting during wire manipulation, were managed with tailored strategies, enabling safe device placement in all patients. Individualized procedural modifications, including novel dual-device and access strategies, enabled safe closure even in anatomically complex cases. At a median follow-up of 17 months, all patients demonstrated sustained defect closure, hemodynamic improvement, and resolution of symptoms. In conclusion, transcatheter VSD closure with the Konar MFO device provides high procedural success and favorable mid-term outcomes in infants < 10 kg, including those with challenging anatomies. Unlike previous reports focusing mainly on procedural success, this study systematically addresses anatomical complexities and mid-term outcomes in infants < 10 kg. Larger multicenter studies with extended follow-up are needed to confirm long-term safety and standardize procedural strategies.

经导管室间隔缺损关闭儿童< 10公斤:解剖挑战和结果与Konar MFO装置。
本研究评估了经导管使用Konar MFO装置封闭室间隔缺损(VSD)的可行性、安全性和中期结果
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pediatric Cardiology
Pediatric Cardiology 医学-小儿科
CiteScore
3.30
自引率
6.20%
发文量
258
审稿时长
12 months
期刊介绍: The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.
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