Kinetic Energy of Left Ventricular Blood Flow Under Pharmacological Stress: Analysis of 4D Flow and Myocardial Perfusion Using Hybrid PET/MR.

IF 1.3 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Computer Assisted Tomography Pub Date : 2025-09-01 DOI:10.1097/RCT.0000000000001795

Keiichiro Endo, Kenji Fukushima, Masataka Katahira, Takatoyo Kiko, Naoyuki Ukon, Ryo Yamakuni, Takeshi Shimizu, Shiro Ishii, Masayoshi Oikawa, Hiroshi Ito, Yasuchika Takeishi

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引用次数: 0

Abstract

Objectives: This study aimed to simultaneously evaluate 4D cardiac magnetic resonance (MR)-derived kinetic energy (KE) of intra-left ventricular (LV) blood flow, wall kinetics, and myocardial perfusion under pharmacological stress in patients with coronary artery disease (CAD) using a hybrid PET/MR system.

Methods: Sixty-five patients (mean 68±12 y; male, 53) with CAD who underwent rest-stress 13N-ammonia PET/MR were included. MR acquisition was performed simultaneously during the PET scan to obtain rest-stress 4D flow, and followed by cine MR to measure LV ejection fraction (LVEF) and myocardial strain, including global longitudinal strain (GLS). The maximum KE during the cardiac cycle was calculated and indexed to the end-diastolic LV volume (maxKEi, μJ/mL) at rest and during stress. Perfusion defect, myocardial flow (MBF), and flow reserve (MFR) were assessed through rest-stress PET.

Results: MaxKEi showed a significant correlation with LVEF and GLS for both rest and stress (r=0.3, P=0.01, r=-0.4, P=0.04 for rest LVEF and GLS; r=0.4, P=0.0009, r=-0.4, P=0.003, for stress LVEF and GLS, respectively). Stress maxKEi showed a significant correlation with stress MBF and MFR (r=0.3, P=0.006, and r=0.3, P=0.03, for stress MBF and MFR, respectively).

Conclusion: Noninvasive assessment of 4D flow MR-derived intra-LV KE demonstrated a significant association with wall kinetics and endothelial function under pharmacological stress.

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药物应激下左室血流动能：PET/MR混合成像4D血流及心肌灌注分析

目的：本研究旨在利用PET/MR混合系统同时评估冠心病（CAD）患者在药物应激下左心室（LV）血流、壁动力学和心肌灌注的4D心脏磁共振（MR）衍生动能（KE）。方法：65例冠心病患者（平均68±12岁，男53岁）行静息应激13n -氨PET/MR检查。在PET扫描期间同时进行MR采集以获得静应力4D血流，然后进行电影MR测量左室射血分数（LVEF）和心肌应变，包括全局纵向应变（GLS）。计算心周期内最大KE，并以静息和应激时左室舒张末容积（maxKEi, μJ/mL）为指标。通过静息应激PET评估灌注缺损、心肌血流（MBF）和血流储备（MFR）。结果：在休息和应激条件下，MaxKEi与LVEF和GLS均呈显著相关（休息条件下LVEF和GLS r=0.3， P=0.01, r=-0.4， P=0.04；应激条件下LVEF和GLS r=0.4， P=0.0009, r=-0.4， P=0.003）。应力maxKEi与应力MBF和MFR呈显著相关（r=0.3， P=0.006；应力MBF和MFR r=0.3， P=0.03）。结论：无创评估4D血流mr衍生的左室内KE显示药物应激下壁动力学和内皮功能显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Computer Assisted Tomography 医学-核医学

CiteScore

2.50

自引率

0.00%

发文量

230

审稿时长

4-8 weeks

期刊介绍： The mission of Journal of Computer Assisted Tomography is to showcase the latest clinical and research developments in CT, MR, and closely related diagnostic techniques. We encourage submission of both original research and review articles that have immediate or promissory clinical applications. Topics of special interest include: 1) functional MR and CT of the brain and body; 2) advanced/innovative MRI techniques (diffusion, perfusion, rapid scanning); and 3) advanced/innovative CT techniques (perfusion, multi-energy, dose-reduction, and processing).