Clinical efficacy and prognosis study of recurrent laryngeal nerve anatomical surgery on serum TNF-a, CRP, interleukins IL-6, IL-10, and IL-1b and outcomes.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yongtao Luo, Hui Cheng
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引用次数: 0

Abstract

Background: This study aimed to evaluate the effects of recurrent laryngeal nerve anatomical exposure during thyroidectomy on serum TNF-a, CRP interleukins IL-6, IL-10, and IL-1b, treatment outcomes, complications, and patient prognosis, with a specific focus on inflammatory and stress markers, including interleukins.

Methods: 110 patients with thyroid lesions undergoing thyroidectomy were randomly assigned to two groups: Expose (n = 55), where the recurrent laryngeal nerve was exposed during surgery, and non-expose (n = 55), where it was not. Various outcome measures were assessed, including surgical efficacy, vocal cord function, serum inflammatory and stress markers (TNF-a, CRP interleukins IL-6, IL-10, and IL-1b), thyroid function changes, postoperative complications (including RLN I), and patient satisfaction. Additionally, quality of life (QoL) was evaluated.

Results: The Expose group exhibited a smaller flap area and shorter hospital stays than the non-expose group, though the surgery took longer (P< 0.05). On postoperative day 30, patients in the Expose group showed lower values of fundamental frequency, Jitter, and Shimmer in vocal cords, indicating improved vocal function (P < 0 .0 5). Furthermore, the Expose group had significantly higher QoL scores and a lower incidence of RLNI (3.64% vs. 20.00% , P< 0.05), with improved surgical satisfaction (96.36% vs. 76.36% , P< 0.05). Notably, the Expose group exhibited reduced inflammatory and stress markers levels, including lower TNF-a, CRP IL-6, and IL-1b, and higher IL-10, which correlated with reduced postoperative pain and inflammation.

Conclusions: Anatomical exposure of the recurrent laryngeal nerve during thyroidectomy enhances postoperative recovery, reduces the incidence of RLNI, and improves both vocal and parathyroid function. It also attenuates inflammatory and stress responses, as indicated by changes in serum cytokines, thereby enhancing quality of life and patient satisfaction. This approach offers significant advantages for patients undergoing thyroidectomy for various thyroid disorders.

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喉返神经解剖手术对血清TNF-a、CRP、白细胞介素IL-6、IL-10、IL-1b及预后的影响
背景:本研究旨在评估甲状腺切除术中喉返神经解剖暴露对血清TNF-a、CRP白细胞介素IL-6、IL-10和IL-1b、治疗结果、并发症和患者预后的影响,并特别关注炎症和应激标志物,包括白细胞介素。方法:将110例甲状腺病变行甲状腺切除术的患者随机分为两组:手术中暴露喉返神经组(n = 55)和不暴露喉返神经组(n = 55)。评估各种结局指标,包括手术疗效、声带功能、血清炎症和应激标志物(TNF-a、CRP白介素IL-6、IL-10和IL-1b)、甲状腺功能改变、术后并发症(包括RLN I)和患者满意度。此外,评估生活质量(QoL)。结果:与非暴露组相比,暴露组皮瓣面积小,住院时间短,手术时间长(P< 0.05)。术后第30天,暴露组患者声带基频、Jitter、Shimmer值降低,提示声带功能改善(P < 0.05)。0 5)。暴露组患者的生活质量评分明显高于对照组(3.64%比20.00%,P< 0.05), RLNI发生率明显低于对照组(96.36%比76.36%,P< 0.05),手术满意度显著提高(P< 0.05)。值得注意的是,暴露组表现出较低的炎症和应激标志物水平,包括较低的TNF-a、CRP IL-6和IL-1b,以及较高的IL-10,这与术后疼痛和炎症的减轻有关。结论:甲状腺切除术中解剖暴露喉返神经可促进术后恢复,减少RLNI的发生率,改善声带和甲状旁腺功能。血清细胞因子的变化表明,它还能减轻炎症和应激反应,从而提高生活质量和患者满意度。该方法为各种甲状腺疾病患者行甲状腺切除术提供了显著的优势。
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来源期刊
Journal of Medical Biochemistry
Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.00
自引率
12.00%
发文量
60
审稿时长
>12 weeks
期刊介绍: The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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