Resistance exercise training similarly improves work efficiency and measured submaximal oxygen consumption during the 6-min walk test in healthy postmenopausal women and breast cancer survivors.

IF 2.7 3区医学 Q2 PHYSIOLOGY

European Journal of Applied Physiology Pub Date : 2025-09-16 DOI:10.1007/s00421-025-05966-0

Macarena Artigas-Arias, Rodrigo Muñoz-Cofre, Nicolás Vidal-Seguel, Andrea Alegría-Molina, Jorge Sapunar, Rui Curi, Gabriel Nasri Marzuca-Nassr

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Abstract

Purpose: This exploratory study aimed to examine the potential effects of a 12-week progressive whole-body resistance exercise training (RET) program on measured submaximal oxygen consumption (submaximal VO₂) and work efficiency during the 6-min walk test (6MWT) in healthy postmenopausal women and breast cancer survivors.

Methods: Twenty-four postmenopausal women (Healthy, HEA; 54 ± 3 years; BMI 26.6 ± 2.7 kg·m^-2; n = 13 and breast cancer survivors, BCS; 52 ± 5 years; BMI 26.8 ± 2.1 kg·m^-2; n = 11) completed a 12-week RET program. Participants were assessed using the 6MWT with a PNOE® metabolic analyzer before and after the intervention. Metabolic and respiratory parameters, including submaximal VO₂ and work efficiency were measured. Data were analyzed using repeated measures ANOVA.

Results: Twelve-week RET improved the distance covered in the 6MWT by 10 ± 11% in the HEA group (from 586.6 ± 27.9 to 642.9 ± 35.9 m) and by 6 ± 16% in the BCS group (from 572.9 ± 62.6 to 604.7 ± 39.9 m) (P < 0.001; η² = 0.54), with no significant differences between the groups (P = 0.175). There was an increase in RER (P < 0.001), ventilation (P = 0.043), and carbohydrate percentage (P < 0.001), along with a decrease in fat consumption percentage (P < 0.001), with no differences between groups (P > 0.05). After 12 weeks of RET, absolute submaximal VO₂ decreased in both groups (P < 0.001), with no differences between them (P > 0.05). The maximum work rate increased (P < 0.001), with no differences between groups (P > 0.05). Work efficiency also improved over time (P < 0.05), with no differences between groups (P > 0.05).

Conclusion: As an exploratory analysis, these findings suggest that a 12-week RET program improved work efficiency and reduced measured submaximal VO₂ during the 6MWT in both populations. The improvements were similar in healthy postmenopausal women and breast cancer survivors.

Trial registration number: NCT05690295.

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在健康绝经后妇女和乳腺癌幸存者的6分钟步行试验中，阻力运动训练同样提高了工作效率和测量的亚最大耗氧量。

目的：本探索性研究旨在探讨12周渐进式全身阻力运动训练（RET）计划对健康绝经后妇女和乳腺癌幸存者在6分钟步行测试（6MWT）中测量的亚最大耗氧量（亚最大摄氧量）和工作效率的潜在影响。方法：24名绝经后妇女（健康，HEA， 54±3岁，BMI 26.6±2.7 kg·m-2, n = 13）和乳腺癌幸存者，BCS， 52±5岁，BMI 26.8±2.1 kg·m-2, n = 11)完成了为期12周的RET计划。在干预前后使用6MWT和PNOE®代谢分析仪对参与者进行评估。测量代谢和呼吸参数，包括亚最大摄氧量和工作效率。数据分析采用重复测量方差分析。结果：12周RET使HEA组6MWT覆盖距离提高了10±11%（从586.6±27.9 m提高到642.9±35.9 m）， BCS组提高了6±16%（从572.9±62.6 m提高到604.7±39.9 m）（P = 0.54），两组间差异无统计学意义（P = 0.175）。RER升高（P < 0.05）。RET 12周后，两组绝对亚极大VO2均下降（P < 0.05）。最大工作速率提高（p0.05）。工作效率也随着时间的推移而提高（P < 0.05）。结论：作为一项探索性分析，这些研究结果表明，12周的RET计划提高了两组人群在6MWT期间的工作效率并降低了测量的亚最大VO2。在健康的绝经后妇女和乳腺癌幸存者中也有类似的改善。试验注册号：NCT05690295。

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来源期刊

European Journal of Applied Physiology 医学-生理学

CiteScore

6.00

自引率

6.70%

发文量

227

审稿时长

3 months

期刊介绍： The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.