Increased in-hospital mortality and readmission risk associated with cardiovascular and cerebrovascular comorbidities in acute exacerbation of COPD patients.

IF 3.4 3区 医学 Q1 RESPIRATORY SYSTEM
Lin Feng, Jiachen Li, Jian Su, Zhaohui Tong, Lirong Liang
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引用次数: 0

Abstract

Background: Cardiovascular and cerebrovascular comorbidities are prevalent in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), but their impact on in-hospital outcomes and the risk of readmission remains unclear. This study aimed to describe the proportions of these comorbidities and assess their influence on patient outcomes.

Methods: Hospital admission records from 2013 to 2020 with a primary discharge diagnosis of AECOPD were retrieved from Beijing Public Health Information Centre database. Comorbidities were identified through discharge diagnoses, while in-hospital outcomes and subsequent readmissions were tracked. Logistic regression model, generalised linear model and subdistributional hazard model were used to evaluate the associations between comorbidities and adverse outcomes.

Results: Among 98 127 patients, cardiovascular comorbidities were present in 78.3% of cases and cerebrovascular comorbidities were present in 30.3% of cases. Patients with cardiovascular comorbidities or cerebrovascular comorbidities or both had prolonged length of stay (ORs: 1.29, 95% CI: 1.23 to 1.35; 1.20, 95% CI: 1.10 to 1.32; 1.52, 95% CI: 1.44 to 1.60) and higher in-hospital mortality (ORs: 1.39, 95% CI: 1.19 to 1.62; 1.34, 95% CI: 1.04 to 1.75; 1.25, 95% CI: 1.06 to 1.48) compared with those without these conditions. Patients with cardiovascular comorbidities and those with both cardiovascular and cerebrovascular comorbidities were at increased risk of readmission (HRs: 1.14, 95% CI: 1.10 to 1.19; 1.19, 95% CI: 1.14 to 1.25), whereas cerebrovascular comorbidities alone were not. The impact of individual comorbidity varied, with heart failure, ischaemic heart disease, arrhythmia, hypertension, ischaemic stroke and cerebrovascular sequelae showing positive associations with adverse outcomes, but the opposite was observed for peripheral arterial disease, arterial stenosis and other cerebrovascular diseases.

Conclusion: Most cardiovascular comorbidities and major cerebrovascular comorbidities are significant predictors of length of stay, in-hospital mortality and readmission in AECOPD patients. These findings highlight the need for targeted management strategies to improve outcomes in this high-risk population. Further research is needed to explore the mechanisms underlying these associations.

Abstract Image

慢性阻塞性肺病急性加重期患者心脑血管合并症与住院死亡率和再入院风险增加相关
背景:心脑血管合并症在慢性阻塞性肺疾病急性加重期(AECOPD)患者中普遍存在,但其对住院结局和再入院风险的影响尚不清楚。本研究旨在描述这些合并症的比例,并评估其对患者预后的影响。方法:从北京市公共卫生信息中心数据库中检索2013 - 2020年初步出院诊断为AECOPD的住院记录。通过出院诊断确定合并症,同时跟踪住院结果和随后的再入院情况。采用Logistic回归模型、广义线性模型和亚分布风险模型评估合并症与不良结局之间的关系。结果:98 127例患者中,心血管合并症占78.3%,脑血管合并症占30.3%。与没有这些疾病的患者相比,有心血管合并症或脑血管合并症或两者兼有的患者住院时间延长(or: 1.29, 95% CI: 1.23至1.35;1.20,95% CI: 1.10至1.32;1.52,95% CI: 1.44至1.60),住院死亡率更高(or: 1.39, 95% CI: 1.19至1.62;1.34,95% CI: 1.04至1.75;1.25,95% CI: 1.06至1.48)。合并心血管合并症和合并心脑血管合并症的患者再入院风险增加(hr: 1.14, 95% CI: 1.10 ~ 1.19; 1.19, 95% CI: 1.14 ~ 1.25),而单独合并脑血管合并症的患者再入院风险没有增加。个体合并症的影响各不相同,心力衰竭、缺血性心脏病、心律失常、高血压、缺血性脑卒中和脑血管后遗症与不良结局呈正相关,但外周动脉疾病、动脉狭窄和其他脑血管疾病与不良结局呈正相关。结论:大多数心血管合并症和主要脑血管合并症是AECOPD患者住院时间、住院死亡率和再入院的重要预测因素。这些发现强调需要有针对性的管理策略来改善这一高危人群的预后。需要进一步的研究来探索这些关联背后的机制。
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来源期刊
BMJ Open Respiratory Research
BMJ Open Respiratory Research RESPIRATORY SYSTEM-
CiteScore
6.60
自引率
2.40%
发文量
95
审稿时长
12 weeks
期刊介绍: BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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