Mechanistic study on the role of multi-pathway autophagy in ovarian aging: literature review.

IF 8.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-09-16 DOI:10.1007/s10495-025-02181-2

Xinyu Zhu, Huihui Li, Tingting Xue, Shu Wang, Ruixiang Zhu, Jiali Luo, Ruotong Ju, Puhua Zhang, Xiangrong Cui, Xuan Jing

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引用次数: 0

Abstract

Ovarian aging is one of the common diseases in the female reproductive system. It is characterized by complex etiologies, involving multiple factors such as genetics, environment, metabolism, and cellular stress. In recent years, autophagy, a crucial cellular self-degradation and repair mechanism, has received substantial attention for its role in maintaining and deteriorating ovarian function. This review systematically summarizes the molecular mechanisms of autophagy and its regulation, as well as the latest research progress of macroautophagy, chaperone-mediated autophagy (CMA) and mitophagy in ovarian aging. Studies have shown that dysregulation of autophagic pathways is closely associated with decreased oocyte quality and reduced ovarian reserve function. Additionally, signaling pathways such as PI3K, AMPK, and mTOR participate in the process of ovarian aging by regulating autophagic activity. Although numerous studies have revealed the critical role of autophagy in ovarian aging, many issues remain to be resolved, such as the crosstalk mechanisms between different autophagic pathways and the precise spatiotemporal dynamics of the autophagic regulatory network. A deep understanding of the regulatory network of multi-pathway autophagy will provide new insights for developing intervention strategies to delay ovarian aging, holding significant scientific and clinical application value.

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多途径自噬在卵巢衰老中的作用机制研究：文献综述。

卵巢老化是女性生殖系统常见病之一。该病病因复杂，涉及遗传、环境、代谢、细胞应激等多种因素。近年来，自噬作为一种重要的细胞自我降解和修复机制，因其在维持和恶化卵巢功能中的作用而受到广泛关注。本文系统综述了自噬的分子机制及其调控，以及巨噬、伴侣介导的自噬（CMA）和线粒体自噬在卵巢衰老中的最新研究进展。研究表明，自噬途径的失调与卵母细胞质量下降和卵巢储备功能下降密切相关。此外，PI3K、AMPK、mTOR等信号通路通过调节自噬活性参与卵巢衰老过程。尽管大量研究揭示了自噬在卵巢衰老中的关键作用，但仍有许多问题有待解决，如不同自噬途径之间的串扰机制以及自噬调节网络的精确时空动态。深入了解多途径自噬的调控网络，将为制定延缓卵巢衰老的干预策略提供新的见解，具有重要的科学和临床应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.