The Synergistic Effects of Trunk Rehabilitation Exercise and Transcranial Direct Current Stimulation on Brain-derived Neurotrophic Factor Levels in Stroke Recovery.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-09-16 DOI:10.4103/aam.aam_230_25

Abdulkareem Muhammad Umar, Mohd Ariff Sharifudin, Naresh Bhaskar Raj, Aisha Ahmad Ahmad

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Abstract

Introduction: Stroke is a prevalent neurological disorder resulting from cerebral ischemia or hemorrhagic injury. Its pathomechanism varies based on etiology and location, leading to complications such as speech loss, impaired motor function, and cognitive decline. This study examines the innovative roles of trunk rehabilitation exercise (TRE), transcranial direct current stimulation (tDCS), and their combination on serum levels of brain-derived neurotrophic factor (BDNF) in patients with stroke.

Materials and methods: A total of 69 stroke survivors were randomized into three intervention groups (IGs): TRE + control intervention (CI) (IG-I, n = 17), tDCS + CI (IG-II, n = 17), combined TRE + tDCS + CI (IG-III, n = 17), and a control group (n = 18). The demographic analysis indicated a predominance of males aged 45-65 years. Serum BDNF levels were measured using an ELISA kit (SL0371Hu). Statistical analyses included factorial analysis of variance to assess the effects of the interventions on serum BDNF levels, with post hoc Tukey's tests to identify differences between the groups.

Results: The analysis revealed a statistically significant difference in serum BDNF levels among the groups (F = 9.530, P = 0.001). The combined IG exhibited the highest mean posttest serum BDNF concentration (181.80 pg/mL), indicating that the combination of TRE and tDCS is more effective than either individual intervention.

Conclusions: These findings highlight the potential of combined rehabilitation strategies to enhance neuroplasticity and recovery in stroke survivors, suggesting that integrating TRE and tDCS may offer improved therapeutic outcomes.

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主干康复训练和经颅直流电刺激对脑卒中恢复后脑源性神经营养因子水平的协同作用。

脑卒中是一种常见的由脑缺血或出血性损伤引起的神经系统疾病。其病理机制因病因和部位而异，可导致语言丧失、运动功能受损和认知能力下降等并发症。本研究探讨了躯干康复运动（TRE）、经颅直流电刺激（tDCS）及其联合治疗对脑卒中患者血清脑源性神经营养因子（BDNF）水平的影响。材料与方法：69例脑卒中幸存者随机分为3组：TRE +对照干预组（CI）（IG-I, n = 17）、tDCS + CI （IG-II, n = 17）、TRE + tDCS + CI联合组（IG-III, n = 17）和对照组（n = 18）。人口统计学分析显示，45-65岁男性居多。采用ELISA试剂盒（SL0371Hu）检测血清BDNF水平。统计分析包括因子方差分析，以评估干预对血清BDNF水平的影响，并使用事后Tukey检验来确定组间差异。结果：各组间血清BDNF水平差异有统计学意义（F = 9.530, P = 0.001）。联合IG组血清BDNF平均浓度最高（181.80 pg/mL），表明TRE联合tDCS比单独干预更有效。结论：这些研究结果强调了联合康复策略在增强脑卒中幸存者神经可塑性和恢复方面的潜力，表明联合TRE和tDCS可能提供更好的治疗结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.