Spotted Fever Group Rickettsioses among Hospitalized Patients and Circulation of Rickettsia in Ticks, Kazakhstan, 2019

IF 6.6 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-09-15 DOI:10.3201/eid3110.250037

Yekaterina V. Bumburidi, Dmitriy V. Berezovskiy, Bakhytkul T. Zhakipbayeva, Roberta Z. Horth, Alexander J. Millman, William L. Nicholson, Galina E. Zemtsova, Victoria Seffren, Elina R. Maltseva, Zhanna A. Berdygulova, Yekaterina O. Ostapchuk, Yuliya V. Perfilyeva, Andrey M. Dmitrovskiy, Zhansulu K. Dukayeva, Zhanna Zh. Shapiyeva

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Abstract

Testing for spotted fever group rickettsioses (SFGR) and the criteria for identifying suspected patients are not routinely used in Kazakhstan. In 2019, we performed a cross-sectional study in 6 sentinel hospitals in the Pavlodar region. We tested 105 hospitalized patients with SFGR-like symptoms by using PCR or indirect immunofluorescence antibody assay and identified 62 cases of SFGR. Most (78%) cases of disease were caused by Rickettsia sibirica and R. raoultii. Cutaneous signs (eschar or rash) were found in 87% of SFGR patients; 79% had a rash, 48% had an eschar, and 13% had neither. Testing of suspected rickettsia cases resulted in a 27% increase in laboratory-detected SFGR over the mean of the previous 3 years (62 vs. 49). Broadening the case definition by including fever, headache, or myalgia and expanding routine testing for suspected cases of SFGR could contribute to improved case detection and earlier treatment.

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2019年哈萨克斯坦蜱类患者斑疹热组立克次体感染及传播情况

哈萨克斯坦没有常规使用斑点热群立克次体病检测和确定疑似患者的标准。2019年，我们在巴甫洛达尔地区的6家哨点医院进行了一项横断面研究。我们对105例有SFGR样症状的住院患者进行了PCR或间接免疫荧光抗体检测，鉴定出62例SFGR。大多数（78%）病例是由西伯利亚立克次体和拉乌尔氏体引起的。87%的SFGR患者有皮肤征象（焦痂或皮疹）；79%的人有皮疹，48%的人有焦痂，13%的人两者都没有。对疑似立克次体病例的检测导致实验室检测到的SFGR比前3年平均增加27%（62对49）。扩大病例定义，包括发热、头痛或肌痛，并扩大对SFGR疑似病例的常规检测，可有助于改进病例发现和早期治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.