Benjamin Lefevre, Gilbert Habib, Bruno Hoen, Christine Selton-Suty, Mary Philip, Nahema Issa, Pierre Danneels, Marine De La Chapelle, Colin Deschanvres, Marie-Line Erpelding, Pierre Tattevin, Audrey Le Bot, Miguel Villamarín, Nuria Fernández-Hidalgo, Christophe Tribouilloy, Emilie Pluquet, Vincent Dubee, Margaret Hannan, Gabriela Dornikova, Emanuele Durante-Mangoni, Lorenzo Bertolino, Rinaldo Focaccia Siciliano, Anna Maria Amaral de Oliveira, Marcelo Goulart Correia, Frédérique Gouriet, Cristiane Lamas
{"title":"<i>Staphylococcus lugdunensis</i> infective endocarditis: a multicentre international observational study.","authors":"Benjamin Lefevre, Gilbert Habib, Bruno Hoen, Christine Selton-Suty, Mary Philip, Nahema Issa, Pierre Danneels, Marine De La Chapelle, Colin Deschanvres, Marie-Line Erpelding, Pierre Tattevin, Audrey Le Bot, Miguel Villamarín, Nuria Fernández-Hidalgo, Christophe Tribouilloy, Emilie Pluquet, Vincent Dubee, Margaret Hannan, Gabriela Dornikova, Emanuele Durante-Mangoni, Lorenzo Bertolino, Rinaldo Focaccia Siciliano, Anna Maria Amaral de Oliveira, Marcelo Goulart Correia, Frédérique Gouriet, Cristiane Lamas","doi":"10.1080/23744235.2025.2556921","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Staphylococcus lugdunensis</i> (SL) can cause infective endocarditis (IE), with unusually high complication and mortality rates. According to the 2023 Duke-ISCVID criteria, blood cultures positive for SL now count as a major microbiological criterion.</p><p><strong>Objectives: </strong>Our aim was to determine the contemporary characteristics of SLIE, and to identify the factors associated with all-cause in-hospital mortality.</p><p><strong>Methods: </strong>Patients with definite SLIE between 2010 and 2024 were included in a collaborative study involving 17 centres in France, Spain, Brazil, Italy, and Ireland.</p><p><strong>Results: </strong>We collected data on 112 patients with definite SLIE. Mean age was 67 ± 18 years, and 76 (67.9%) were males. Nosocomial and healthcare-related non-nosocomial SLIE accounted for 15.2% and 16.1% of cases, respectively. Prosthetic valves and cardiac implantable electronic devices (CIED) were involved in 36.6% and 10.7% of cases, respectively. Emboli occurred in 50%, heart failure in 32%, acute kidney injury in 39.4%, and perivalvular abscesses in 20.5% of cases. All strains were methicillin susceptible. Valve surgery was performed in 47 (42%) and CIED removal in 10 (8.9%) patients. All-cause in-hospital mortality was 29.5%. Variables associated with mortality were age (OR 1.10 per one-year increment, 95%CI [1.08-1.31], <i>p</i> < 0.001), malignancy (OR 26.22, [3.78-181.72], <i>p</i> < 0.001), a new severe mitral regurgitation (OR 17.10, [2.81-104.09], <i>p</i> = 0.002), paravalvular abscess (OR 63.40, [6.24-644.03], <i>p</i> < 0.001), and new high-degree atrioventricular block (OR 27.76, [2.49-309.82], <i>p</i> = 0.007).</p><p><strong>Conclusion: </strong>This international multicentre study confirms that SLIE mimics <i>Staphylococcus aureus</i> IE, particularly with regard to aggressiveness, healthcare-related acquisition, complications, and mortality. Of note, all SL isolates were methicillin-susceptible.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23744235.2025.2556921","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Staphylococcus lugdunensis (SL) can cause infective endocarditis (IE), with unusually high complication and mortality rates. According to the 2023 Duke-ISCVID criteria, blood cultures positive for SL now count as a major microbiological criterion.
Objectives: Our aim was to determine the contemporary characteristics of SLIE, and to identify the factors associated with all-cause in-hospital mortality.
Methods: Patients with definite SLIE between 2010 and 2024 were included in a collaborative study involving 17 centres in France, Spain, Brazil, Italy, and Ireland.
Results: We collected data on 112 patients with definite SLIE. Mean age was 67 ± 18 years, and 76 (67.9%) were males. Nosocomial and healthcare-related non-nosocomial SLIE accounted for 15.2% and 16.1% of cases, respectively. Prosthetic valves and cardiac implantable electronic devices (CIED) were involved in 36.6% and 10.7% of cases, respectively. Emboli occurred in 50%, heart failure in 32%, acute kidney injury in 39.4%, and perivalvular abscesses in 20.5% of cases. All strains were methicillin susceptible. Valve surgery was performed in 47 (42%) and CIED removal in 10 (8.9%) patients. All-cause in-hospital mortality was 29.5%. Variables associated with mortality were age (OR 1.10 per one-year increment, 95%CI [1.08-1.31], p < 0.001), malignancy (OR 26.22, [3.78-181.72], p < 0.001), a new severe mitral regurgitation (OR 17.10, [2.81-104.09], p = 0.002), paravalvular abscess (OR 63.40, [6.24-644.03], p < 0.001), and new high-degree atrioventricular block (OR 27.76, [2.49-309.82], p = 0.007).
Conclusion: This international multicentre study confirms that SLIE mimics Staphylococcus aureus IE, particularly with regard to aggressiveness, healthcare-related acquisition, complications, and mortality. Of note, all SL isolates were methicillin-susceptible.
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