Pineal Gland and Melatonin are Associated with Serum Element Metabolism in Rats.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2025-08-19 eCollection Date: 2025-01-01 DOI:10.29399/npa.28765

Aylin Üstün, Zeynep Köykun, Haluk Gümüş, Bayram Yılmaz, Rasim Moğulkoç, Abdulkerim Kasım Baltacı

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引用次数: 0

Abstract

Introduction: The aim of this study is to investigate the relationship of melatonin supplementation with serum element metabolism in pinealectomized rats.

Methods: The research was conducted on 32 adult male Spraque-Dawley rats. The study protocol was approved by the local animal ethics committee.Animals were divided into four equal groups. Control (Group 1), Melatonin (Group 2), Pinealectomy "Px" (Group 3), Pinealectomy+melatonin (Group 4). Animals in groups 2 and 4 were given intraperitoneal (ip) melatonin support (4 weeks/day; 3 mg/kg melatonin). Animals in groups 3 and 4 underwent pinealectomy under general anesthesia. At the end of the applications, serum element levels were determined by atomic emission (μg/dl) in the blood samples taken from the sacrificed animals.

Results: While pinealectomy increased chromium and manganese levels in Group 3 (p<0.001), it caused significant suppression of magnesium, calcium and zinc levels (p<0.001). Melatonin supplementation in pinealectomized animals (Group 4) treated the impairments in the mentioned parameters.

Conclusion: The results of the current study show that the melatonin hormone secreted from the pineal gland has a regulatory effect on serum element metabolism. This study is the first to examine the relationship between the pineal gland and element metabolism as a whole.

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松果体和褪黑素与大鼠血清元素代谢相关。

摘要：本研究旨在探讨褪黑素补充与去松果体大鼠血清元素代谢的关系。方法：对32只成年雄性Spraque-Dawley大鼠进行研究。本研究方案经当地动物伦理委员会批准。动物被分成四组。对照组（1组）、褪黑素组（2组）、松果体“Px”切除术（3组）、松果体切除术+褪黑素（4组）。第2组和第4组给予褪黑素腹腔内支持（4周/天，褪黑素3 mg/kg）。3、4组在全身麻醉下行松果体切除术。应用结束时，采用原子发射法（μg/dl）测定牺牲动物血样中的血清元素水平。结论：本研究结果表明松果体分泌的褪黑激素对血清元素代谢具有调节作用。本研究首次从整体上考察了松果体与元素代谢之间的关系。

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.