Apremilast for refractory major recurrent aphthous stomatitis involving the posterior pharyngeal wall: a case report.

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-19 DOI:10.1016/j.oooo.2025.08.003

Tinglan Yang, Jiankang Yang, Qing Liu, Zhenlai Zhu

引用次数: 0

Abstract

This case report describes a 37-year-old woman with refractory major recurrent aphthous stomatitis (RAS) who presented with a persistent 10-month posterior pharyngeal ulcer that was unresponsive to conventional treatments. Laboratory tests revealed elevated IL-6 and C-reactive protein. After excluding other related diseases, treatment with apremilast led to complete ulcer healing within 3 months, with normalization of IL-6 and no new ulcers during 8 months of follow-up. This case suggests the potential therapeutic benefits of apremilast in severe pharyngeal RAS refractory to conventional therapies.

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阿普米司特治疗累及咽后壁的复发性口疮性难治性口腔炎1例。

本病例报告描述了一名37岁女性难治性复发性口疮性口炎（RAS），她表现为持续10个月的咽后溃疡，对常规治疗无反应。实验室检查显示IL-6和c反应蛋白升高。排除其他相关疾病后，阿普米司特治疗3个月内溃疡完全愈合，IL-6恢复正常，随访8个月无新溃疡发生。本病例提示阿普米司特对常规治疗难治性严重咽部RAS的潜在治疗益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.