Efficacy of two calcifediol supplementation regimens in older adults post-hip fracture surgery. A clinical trial.

IF 3.6 3区医学 Q2 GERIATRICS & GERONTOLOGY

European Geriatric Medicine Pub Date : 2025-09-15 DOI:10.1007/s41999-025-01303-y

Leonor Cuadra-Llopart, Antoni Salvà Casanovas, Georgina Cerdà Mas, Esther Jovell-Fernández

{"title":"Efficacy of two calcifediol supplementation regimens in older adults post-hip fracture surgery. A clinical trial.","authors":"Leonor Cuadra-Llopart, Antoni Salvà Casanovas, Georgina Cerdà Mas, Esther Jovell-Fernández","doi":"10.1007/s41999-025-01303-y","DOIUrl":null,"url":null,"abstract":"Background: Vitamin D deficiency is highly prevalent among older adults with hip fracture and may compromise recovery. This study evaluated the effectiveness of two calcifediol supplementation regimens in correcting serum 25-hydroxyvitamin D [25(OH)D] levels and supporting functional recovery.Methods: In this randomized clinical trial, 50 patients aged ≥ 75 years with hip fracture and serum 25(OH)D < 30 ng/mL were assigned to receive calcifediol 266 μg daily for 5 days (intervention group, IG) or 266 μg weekly for 5 weeks (control group, CG). Primary endpoints were the proportion achieving 25(OH)D > 30 ng/mL, change in parathyroid hormone, and functional recovery assessed at discharge and at 3, 6, and 12 months post-fracture.Results: The mean age was 86 years; 64% were women. Baseline 25(OH)D was 13.3 ng/mL in the IG and 12.0 ng/mL in the CG. After one month, both groups showed increased concentrations (38.2 vs. 35.2 ng/mL; p = 0.50). PTH decreased more in the IG (43.5 vs. 75.2 pg/mL; p = 0.001). Approximately 50% of patients showed clinically meaningful functional improvement. Multivariate analysis indicated lower relative functional gain in CG participants who did not achieve optimal 25(OH)D levels (67.2 vs. 43.7; p = 0.06). No significant differences in long-term functional outcomes were observed between groups.Conclusions: Both daily and weekly calcifediol regimens effectively corrected vitamin D deficiency in older adults with hip fracture. Functional improvement at discharge was observed in both groups and was clinically relevant.Trial registration: ClinicalTrials.gov Identifier: NCT03213886 (Date of registration: 11/07/2017).","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Geriatric Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s41999-025-01303-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Vitamin D deficiency is highly prevalent among older adults with hip fracture and may compromise recovery. This study evaluated the effectiveness of two calcifediol supplementation regimens in correcting serum 25-hydroxyvitamin D [25(OH)D] levels and supporting functional recovery.

Methods: In this randomized clinical trial, 50 patients aged ≥ 75 years with hip fracture and serum 25(OH)D < 30 ng/mL were assigned to receive calcifediol 266 μg daily for 5 days (intervention group, IG) or 266 μg weekly for 5 weeks (control group, CG). Primary endpoints were the proportion achieving 25(OH)D > 30 ng/mL, change in parathyroid hormone, and functional recovery assessed at discharge and at 3, 6, and 12 months post-fracture.

Results: The mean age was 86 years; 64% were women. Baseline 25(OH)D was 13.3 ng/mL in the IG and 12.0 ng/mL in the CG. After one month, both groups showed increased concentrations (38.2 vs. 35.2 ng/mL; p = 0.50). PTH decreased more in the IG (43.5 vs. 75.2 pg/mL; p = 0.001). Approximately 50% of patients showed clinically meaningful functional improvement. Multivariate analysis indicated lower relative functional gain in CG participants who did not achieve optimal 25(OH)D levels (67.2 vs. 43.7; p = 0.06). No significant differences in long-term functional outcomes were observed between groups.

Conclusions: Both daily and weekly calcifediol regimens effectively corrected vitamin D deficiency in older adults with hip fracture. Functional improvement at discharge was observed in both groups and was clinically relevant.

Trial registration: ClinicalTrials.gov Identifier: NCT03213886 (Date of registration: 11/07/2017).

查看原文本刊更多论文

两种钙化二醇补充方案在老年人髋部骨折术后的疗效。临床试验。

背景：维生素D缺乏症在髋部骨折的老年人中非常普遍，并可能影响康复。本研究评估了两种钙化二醇补充方案在纠正血清25-羟基维生素D [25(OH)D]水平和支持功能恢复方面的有效性。方法：在这项随机临床试验中，50例年龄≥75岁的髋部骨折患者，在出院时和骨折后3、6和12个月评估血清25(OH)D 30 ng/mL、甲状旁腺激素变化和功能恢复情况。结果：患者平均年龄86岁；其中64%是女性。IG组25(OH)D基线值为13.3 ng/mL， CG组为12.0 ng/mL。1个月后，两组浓度均升高（38.2 vs. 35.2 ng/mL; p = 0.50）。PTH在IG中下降更多（43.5 vs. 75.2 pg/mL; p = 0.001）。大约50%的患者表现出临床意义上的功能改善。多变量分析表明，未达到最佳25(OH)D水平的CG参与者的相对功能增益较低（67.2 vs 43.7; p = 0.06）。两组间长期功能结果无显著差异。结论：每日和每周的钙化二醇方案都能有效地纠正老年髋部骨折患者的维生素D缺乏症。两组患者出院时功能均有改善，且具有临床相关性。试验注册：ClinicalTrials.gov标识符：NCT03213886（注册日期：11/07/2017）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Geriatric Medicine GERIATRICS & GERONTOLOGY-

CiteScore

6.70

自引率

2.60%

发文量

114

审稿时长

6-12 weeks

期刊介绍： European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine. The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.