Effective Plant-Derived Proteins and Peptides in Leukemia Treatment.

IF 1.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Protein and Peptide Letters Pub Date : 2025-09-10 DOI:10.2174/0109298665395842250814085828

Zahra Moghaddasi, Azam Bolhassani, Elnaz Agi

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引用次数: 0

Abstract

Leukemia is one of the most prevalent malignancies worldwide that causes the unusual evolution of hematopoietic stem cells. The type of leukemia determines the optimal treatment plan and the patient's survival. However, finding safer and more effective medications and developing novel therapeutic strategies are still the most challenging research topics. Nowadays, over half of the medications used to treat cancer are derived from natural ingredients. Medicinal plants are a reliable natural source of anti-leukemic medications. Plant-derived biologically active compounds, including secondary metabolites, have long been considered extremely valuable for treating various human illnesses. However, the limitations of secondary metabolites have led scientists to seek alternative biologically active compounds. Plant-derived proteins and peptides have recently been explored as potential treatments for various human ailments, showing anti-microbial, anti-oxidant, anti-HIV, anti-cancer, ribosome-inactivating, and neuromodulatory properties. Until now, no review article has documented the biologically active proteins and peptides against leukemia. This review article explores the therapeutic properties of plant-derived proteins and peptides against leukemia.

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有效的植物源性蛋白和多肽治疗白血病。

白血病是世界上最常见的恶性肿瘤之一，它引起造血干细胞的异常进化。白血病的类型决定了最佳的治疗方案和患者的生存。然而，寻找更安全、更有效的药物和开发新的治疗策略仍然是最具挑战性的研究课题。如今，用于治疗癌症的药物中有一半以上是从天然成分中提取的。药用植物是抗白血病药物的可靠天然来源。植物衍生的生物活性化合物，包括次生代谢物，长期以来被认为对治疗各种人类疾病极有价值。然而，次生代谢物的局限性促使科学家们寻求替代的生物活性化合物。植物来源的蛋白质和多肽最近被探索作为各种人类疾病的潜在治疗方法，显示出抗微生物、抗氧化、抗艾滋病毒、抗癌、核糖体失活和神经调节特性。到目前为止，还没有一篇综述文章记录了抗白血病的生物活性蛋白和肽。本文综述了植物源性蛋白和多肽对白血病的治疗特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis