Immune function (serum IL-4 and IL-5), nutritional status, and clinical outcomes in children with bronchial asthma after vitamin D supplementation.

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-08-21 DOI:10.5937/jomb0-56915

Xiangli Xiao, Ranran Wang, Li Qin

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Abstract

Background: This study explores the combined therapeutic effects of pediatric massage and vitamin D supplementation on the nutritional status, immune function (serum IL-4 and IL-5), and clinical outcomes in children with Bronchial asthma (BA).

Methods: A total of 60 children diagnosed with BA were randomly assigned to one of two groups: a control group receiving conventional treatment alone and an experimental group receiving conventional treatment alongside pediatric massage and daily vitamin D supplementation. Both groups were monitored over two months for changes in clinical symptoms, immune markers (CD 3+, CD4+, CD4+/CD8 + ratio), nutritional protein levels (albumin, transferrin, prealbumin, and total protein), and recurrence rates.

Results: The experimental group showed significantly faster symptom relief and improved immune function than the control group. This included enhanced immune markers, such as increased CD3+ and CD4+ counts and an improved CD 4+/CD 8+ ratio. Nutritional status also improved, as evidenced by higher levels of albumin, transferrin, prealbumin, and total protein. Additionally, the recurrence rate in the experimental group was notably lower (10%) compared to the control group. The experimental group also exhibited reduced levels of inflammatory cytokines, including IL-4 and IL-5, suggesting a beneficial effect on immune modulation.

Conclusions: The combination of pediatric acupressure and vitamin D supplementation can improve immune function and inflammatory response in children with BA, which is of clinical value.

Abstract Image

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补充维生素D后支气管哮喘患儿的免疫功能（血清IL-4和IL-5）、营养状况和临床结局

背景：本研究探讨小儿推拿联合补充维生素D对支气管哮喘（BA）患儿营养状况、免疫功能（血清IL-4和IL-5）及临床结局的影响。方法：将60例确诊为BA的儿童随机分为两组：对照组单独接受常规治疗，实验组在常规治疗的同时进行小儿推拿和每日补充维生素D。监测两组临床症状、免疫标志物（cd3 +、CD4+、CD4+/CD8 +比值）、营养蛋白水平（白蛋白、转铁蛋白、白蛋白前和总蛋白）和复发率的变化超过两个月。结果：实验组症状缓解速度明显快于对照组，免疫功能明显改善。这包括免疫标志物的增强，如CD3+和CD4+计数的增加和CD4+ / cd8 +比率的改善。营养状况也得到改善，如白蛋白、转铁蛋白、前白蛋白和总蛋白水平的提高。此外，实验组的复发率明显低于对照组（10%）。实验组还表现出炎症细胞因子水平降低，包括IL-4和IL-5，表明对免疫调节有有益作用。结论：小儿指压配合补充维生素D可改善BA患儿的免疫功能和炎症反应，具有临床应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.