HLAtools, Searching Shared HLA Amino Acid Residue Prevalence, and the Global Frequency Browsers: New Computational Resources for Working With HLA Data and Visualizing Global Patterns of HLA Variation.

IF 1.1 4区 医学 Q3 GENETICS & HEREDITY
Livia Tran, Ryan Nickens, Vinh Luu, Effie W Petersdorf, Steven J Mack
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引用次数: 0

Abstract

The highly polymorphic HLA genes inform susceptibility and resistance to infectious and autoimmune diseases and cancers and are key for successful solid-organ and stem-cell transplantation therapies. Over 41,000 HLA alleles are known and are unevenly distributed across the human population. Here, we describe HLAtools, Searching Shared HLA Amino-Acid Residue Prevalence (SSHAARP) and the Global Frequency Browser (GFB), new informatic tools developed to facilitate working with HLA data and visualizing the global distribution of HLA variants in human populations. HLAtools is an R package that consumes static resources for HLA alleles and sequences and makes these data locally computable alongside data-query, data-customization and data-analysis functions. The package further includes new reference datasets that dissect and catalogue HLA regions and HLA gene structures and provide insight into the organization of HLA pseudogenes and gene fragments. SSHAARP is an R package that describes the frequency distributions of individual HLA haplotypes, alleles and amino-acid motifs as global heatmaps. Allele frequency maps for more than 800 HLA alleles can be browsed using the GFB web and mobile applications. HLAtools and SSHAARP are available from the Comprehensive R Archive Network, and the GFB apps are available on GitHub.

HLA工具,搜索共享的HLA氨基酸残基流行率和全球频率浏览器:处理HLA数据和可视化HLA变异全球模式的新计算资源。
高度多态性的HLA基因告知感染性和自身免疫性疾病和癌症的易感性和抵抗力,是成功的实体器官和干细胞移植治疗的关键。已知的HLA等位基因超过41,000个,在人群中分布不均匀。在这里,我们描述了HLA工具,搜索共享HLA氨基酸残基流行率(SSHAARP)和全球频率浏览器(GFB),这些新的信息工具的开发有助于处理HLA数据和可视化HLA变异在人群中的全球分布。HLA工具是一个R包,它消耗HLA等位基因和序列的静态资源,并使这些数据与数据查询、数据定制和数据分析功能一起在本地计算。该软件包进一步包括新的参考数据集,剖析和编目HLA区域和HLA基因结构,并提供对HLA假基因和基因片段的组织的见解。SSHAARP是一个R包,它将单个HLA单倍型、等位基因和氨基酸基序的频率分布描述为全球热图。超过800个HLA等位基因的等位基因频率图可以通过GFB网站和移动应用程序浏览。hlattools和SSHAARP可以从综合R档案网络中获得,而GFB应用程序可以在GitHub上获得。
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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
48
审稿时长
6-12 weeks
期刊介绍: The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.
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