Investigating Causal Links Between Uterine Prolapse, Urinary Tract Infections, and Lower Urinary Tract Symptoms: A Two-Sample Mendelian Randomization Study.

IF 2.6 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S530763

Xiaoyue Zhu, Chunyan Hu, Anneng Hu, Yongbo Zheng, Junyang Li, Fuwen Luo, Lin Yang, Yuhang Lin, Xiaodong Yu

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引用次数: 0

Abstract

Background: Uterine prolapse (UP), a subtype of pelvic organ prolapse (POP), frequently coexists with urinary tract infections (UTIs) and lower urinary tract symptoms (LUTS), including urinary frequency (UF), urinary incontinence (UI), and urinary retention (UR), is a common pelvic floor dysfunction disorder in women. However, the causal relationship between these conditions remains controversial. This study aims to fill this gap by applying two-sample Mendelian randomization.

Methods: A two-sample Mendelian randomization (MR) study was conducted to genetically evaluate associations between UP and UTIs/LUTS. The inverse variance weighting (IVW) method served as the primary analysis, supplemented by sensitivity analyses to assess the validity and reliability of results.

Results: MR analysis suggested a potential causal link between UP and increased risk of UTIs (p = 0.048). No causal associations were observed between UP and UF, UI, or UR. Sensitivity analyses confirmed stability of results, with no evidence of heterogeneity or horizontal pleiotropy among instrumental variables (IVs).

Conclusion: UP may act as a risk factor for UTIs, though further validation is needed given the borderline statistical significance. No clear causal relationships were identified between UP and UF, UI, or UR.

Abstract Image

查看原文本刊更多论文

调查子宫脱垂、尿路感染和下尿路症状之间的因果关系：一项双样本孟德尔随机研究。

背景：子宫脱垂（UP）是盆腔器官脱垂（POP）的一种亚型，常伴有尿路感染（uti）和下尿路症状（LUTS），包括尿频（UF）、尿失禁（UI）和尿潴留（UR），是女性常见的盆底功能障碍。然而，这些条件之间的因果关系仍然存在争议。本研究旨在通过应用双样本孟德尔随机化来填补这一空白。方法：采用双样本孟德尔随机化（MR）研究，从遗传学角度评估UP与uti /LUTS之间的关联。以方差反加权法（IVW）为主要分析方法，辅以敏感性分析来评估结果的效度和信度。结果：MR分析表明UP与uti风险增加之间存在潜在的因果关系（p = 0.048）。未观察到UP与UF、UI或UR之间的因果关系。敏感性分析证实了结果的稳定性，没有证据表明工具变量（IVs）之间存在异质性或水平多效性。结论：UP可能作为尿路感染的危险因素，尽管考虑到临界统计学意义，需要进一步验证。未发现UP与UF、UI或UR之间存在明确的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.