Understanding Sex Differences in Substance Use and Substance Use Disorders: A Moving Target.

IF 3.2 3区医学 Q1 SUBSTANCE ABUSE

Journal of Addiction Medicine Pub Date : 2025-09-15 DOI:10.1097/ADM.0000000000001584

Valentina Lorenzetti, Erynn Christensen, Rita Valentino

引用次数: 0

Abstract

Sex differences in the prevalence of substance use disorders (SUD) are well recognized. While a greater proportion of males endorse consuming substances and SUDs, the gap between the sexes has been narrowing over time, due to an increased rate of substance use among females. Yet, the mechanisms underlying sex differences in SUD are unclear, and evidence is lacking to inform the development of personalised preventions and treatment for males and females. The neuroscientific evidence to date is inadequate to explain sex differences in SUD, due to a range of methodological issues (eg, study design, recruitment, and statistical modelling). A harmonised multidisciplinary approach that considers sex at each stage of the research cycle is required to create new mechanistic knowledge and to inform the identification of prevention and treatment targets for males and females with an SUD.

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了解物质使用和物质使用障碍的性别差异：一个移动的目标。

物质使用障碍（SUD）患病率的性别差异是公认的。虽然越来越多的男性支持使用药物和sud，但随着时间的推移，由于女性药物使用率的增加，两性之间的差距一直在缩小。然而，SUD的性别差异背后的机制尚不清楚，并且缺乏证据来为男性和女性的个性化预防和治疗提供信息。由于一系列方法学问题（如研究设计、招募和统计建模），迄今为止的神经科学证据不足以解释SUD的性别差异。需要一个协调的多学科方法，在研究周期的每个阶段考虑性别，以创造新的机制知识，并为患有SUD的男性和女性的预防和治疗目标的确定提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addiction Medicine 医学-药物滥用

CiteScore

6.10

自引率

9.10%

发文量

260

审稿时长

>12 weeks

期刊介绍： The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.