Therapeutic outcomes and inflammatory modulation of inhaled N-acetylcysteine bronchoalveolar lavage in severe pneumonia.

IF 1.6 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

American journal of translational research Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.62347/CDJX3226

Shuzhen Long, Huazhao Qin, Jing Guo, Lihua Liu

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Abstract

Objective: To evaluate the therapeutic efficacy of inhaled N-acetylcysteine (NAC) bronchoalveolar lavage (iNAC-BAL) in severe pneumonia (SP) and explore its effects on inflammatory cytokines modulation.

Methods: A total of 146 SP cases were assigned to two groups: the control group received bronchoalveolar lavage with isotonic saline (0.9% NaCl) alone, while the observation group received additional NAC aerosol inhalation. Clinical efficacy, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, intensive care unit (ICU) stay, duration of ventilator dependence, adverse reactions, symptom resolution times, respiratory mechanics, pulmonary function, inflammatory cytokines, and humoral immunity were assessed and compared between the two groups.

Results: The observation group achieved better therapeutic effects (P=0.007), with significantly lower APACHE II scores, shorter ICU stays, reduced ventilator dependence, faster symptom resolution, and fewer adverse events (all P<0.05). Additionally, respiratory dynamics, lung function, inflammatory cytokines, and humoral immunity improved markedly in the observation group compared with the control group (all P<0.05).

Conclusion: iNAC-BAL demonstrates significant clinical efficacy and potent anti-inflammatory effects in the management of SP.

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吸入n -乙酰半胱氨酸支气管肺泡灌洗治疗重症肺炎的疗效和炎症调节作用。

目的：评价吸入n -乙酰半胱氨酸（NAC）支气管肺泡灌洗（iNAC-BAL）治疗重症肺炎（SP）的疗效，并探讨其对炎症因子调节的影响。方法：将146例SP患者分为两组，对照组采用等渗盐水（0.9% NaCl）单独支气管肺泡灌洗，观察组在此基础上加用NAC气雾剂吸入。评估并比较两组患者的临床疗效、急性生理和慢性健康评估（APACHE）评分、重症监护病房（ICU）住院时间、呼吸机依赖时间、不良反应、症状缓解时间、呼吸力学、肺功能、炎症因子和体液免疫。结果：观察组治疗效果较好（P=0.007），患者APACHEⅱ评分明显降低，ICU住院时间缩短，呼吸机依赖性降低，症状缓解速度加快，不良事件减少（均P < 0.05）。结论：iNAC-BAL治疗SP临床疗效显著，抗炎作用强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

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