mRNA Fate in Human Cells; Degradation and Subcellular Localisation

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2025-09-14 DOI:10.1002/cbf.70119

Forogh Jafari, Kamalpreet Kaur, Jawairia Umar Khan, Farah Al Hlow, Mohammad Sadraeian, Milad Mohkam, Yuen Yee Cheng

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引用次数: 0

Abstract

The fate of mRNA in human cells is a critical aspect of gene regulation, encompassing both post-translation degradation and subcellular localization. This review explores the critical role of mRNA fate in human cells, focusing on post-translation degradation and subcellular localization. mRNA degradation, including mechanisms like nonsense-mediated decay, ensures the elimination of defective and unnecessary transcripts, thereby preventing harmful protein accumulation. Simultaneously, subcellular localization directs mRNA to specific organelles, such as the endoplasmic reticulum and mitochondria, facilitating localized protein synthesis essential for cellular function. We highlight the importance of these processes in maintaining cellular homeostasis, particularly in neurons and cancer cells, where dysregulation can lead to disease. By understanding these processes, new therapeutic strategies can be developed to target diseases associated with mRNA dysregulation.

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mRNA在人细胞中的命运降解和亚细胞定位

mRNA在人类细胞中的命运是基因调控的一个关键方面，包括翻译后降解和亚细胞定位。这篇综述探讨了mRNA命运在人类细胞中的关键作用，重点是翻译后降解和亚细胞定位。mRNA降解，包括无义介导的衰变等机制，确保消除有缺陷和不必要的转录本，从而防止有害蛋白质的积累。同时，亚细胞定位将mRNA定向到特定的细胞器，如内质网和线粒体，促进细胞功能所必需的局部蛋白质合成。我们强调这些过程在维持细胞稳态中的重要性，特别是在神经元和癌细胞中，其中失调可能导致疾病。通过了解这些过程，可以开发新的治疗策略来靶向与mRNA失调相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.