Acoustic Cardiography (ACG) for Left Ventricular Ejection Time (LVET) Monitoring in Preeclampsia Risk Prediction

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Chunping Tang, Xinxin Zhang, Miao Wang, Yiyuan Xiong, Yingxia Zhu, Qiong Huang, Ningtian Zhou
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Abstract

Background

Preeclampsia (PE), a leading cause of maternal morbidity, lacks reliable early biomarkers. This study evaluates acoustic cardiography (ACG) for noninvasive left ventricular ejection time (LVET) monitoring and its predictive value in PE.

Methods

In an observational case-control study, 59 pregnant women (28 controls, 31 PE cases) underwent synchronized ECG-phonocardiogram (PCG) monitoring using AI-driven devices. LVET, Q2S2Max, and hemodynamic parameters were analyzed.

Hypothesis

ACG predict PE risk via LVET monitoring.

Results

Significantly prolonged LVET in the PE group (320.28 ± 26.79 ms vs. 301.32 ± 35.42 ms, p = 0.026), correlating with increased cardiac afterload. ROC analysis revealed moderate diagnostic efficacy for LVET alone (AUC = 0.658, sensitivity 72.4%, specificity 57.1%). Combining LVET with hypertension history enhanced performance (AUC = 0.776, specificity 77.8%), reducing false positives. Elevated Q2S2Max in PE (426.10 ± 29.46 vs. 403.96 ± 33.28, p = 0.010) indicated vascular stiffness, suggesting early vascular-cardiac coupling dysfunction.

Conclusions

ACG-derived parameters, integrated with clinical risk factors, demonstrated cost-effective, dynamic monitoring potential for early PE detection, particularly in resource-limited settings. While limited by sample size and single-center design, this study highlights ACG as a promising tool for cardiovascular risk stratification in pregnancy, warranting further validation in larger cohorts.

Abstract Image

超声心动图(ACG)监测左室射血时间(LVET)在子痫前期风险预测中的应用
背景子痫前期(PE)是孕产妇发病的主要原因,缺乏可靠的早期生物标志物。本研究评估声学心动图(ACG)在无创左心室射血时间(LVET)监测中的应用及其对PE的预测价值。方法在一项观察性病例-对照研究中,59例孕妇(对照组28例,PE例31例)采用人工智能驱动设备进行同步心电图-心音图(PCG)监测。分析LVET、Q2S2Max及血流动力学参数。假设ACG通过LVET监测预测PE风险。结果PE组LVET明显延长(320.28±26.79 ms vs 301.32±35.42 ms, p = 0.026),与心脏后负荷增加相关。ROC分析显示,单独使用LVET诊断效果中等(AUC = 0.658,敏感性72.4%,特异性57.1%)。LVET与高血压病史结合可提高诊断效率(AUC = 0.776,特异性77.8%),减少假阳性。PE Q2S2Max升高(426.10±29.46 vs 403.96±33.28,p = 0.010)提示血管僵硬,提示早期血管-心脏偶联功能障碍。结论acg衍生参数与临床风险因素相结合,具有成本效益,具有动态监测早期肺泡检测的潜力,特别是在资源有限的情况下。虽然受样本量和单中心设计的限制,本研究强调ACG作为妊娠期心血管风险分层的有前景的工具,需要在更大的队列中进一步验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Cardiology
Clinical Cardiology 医学-心血管系统
CiteScore
5.10
自引率
3.70%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.
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