Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine

IF 3.1 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-09-15 DOI:10.1002/cam4.71187

Sama Barati, Sahar Ghoflchi, Pejman Hosseinzadeh, Sobhan Pouramini, Hossein Hosseini, Mohammad Jalili-Nik

{"title":"Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine","authors":"Sama Barati, Sahar Ghoflchi, Pejman Hosseinzadeh, Sobhan Pouramini, Hossein Hosseini, Mohammad Jalili-Nik","doi":"10.1002/cam4.71187","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Glioblastoma (GBM) is an aggressive primary brain tumor with poor prognosis and low survival rates. Standard treatments, such as surgery and radiotherapy, are limited by tumor infiltration and resistance. To review current vaccine strategies for GBM, including peptide, virotherapy, cell-based, and genetic vaccines, with a focus on mRNA vaccines.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Relevant literature on GBM vaccines and immunotherapy was reviewed to summarize design, mechanisms, and potential clinical applications.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Cancer vaccines aim to activate the immune system to target tumor cells. mRNA vaccines are promising due to their flexibility, rapid production, and strong immune activation, though clinical investigation is ongoing.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Vaccine-based therapies, particularly mRNA vaccines, hold potential for personalized GBM treatment, but further studies are needed to confirm efficacy and optimize use.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 18","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.71187","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.71187","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Glioblastoma (GBM) is an aggressive primary brain tumor with poor prognosis and low survival rates. Standard treatments, such as surgery and radiotherapy, are limited by tumor infiltration and resistance. To review current vaccine strategies for GBM, including peptide, virotherapy, cell-based, and genetic vaccines, with a focus on mRNA vaccines.

Methods

Relevant literature on GBM vaccines and immunotherapy was reviewed to summarize design, mechanisms, and potential clinical applications.

Results

Cancer vaccines aim to activate the immune system to target tumor cells. mRNA vaccines are promising due to their flexibility, rapid production, and strong immune activation, though clinical investigation is ongoing.

Conclusion

Vaccine-based therapies, particularly mRNA vaccines, hold potential for personalized GBM treatment, but further studies are needed to confirm efficacy and optimize use.

Abstract Image

查看原文本刊更多论文

有希望的胶质母细胞瘤肿瘤疫苗治疗：mRNA疫苗的焦点

胶质母细胞瘤（GBM）是一种侵袭性原发性脑肿瘤，预后差，生存率低。标准治疗，如手术和放疗，受到肿瘤浸润和耐药性的限制。回顾目前针对GBM的疫苗策略，包括多肽、病毒疗法、细胞疫苗和基因疫苗，重点是mRNA疫苗。方法回顾有关GBM疫苗和免疫治疗的相关文献，总结疫苗的设计、作用机制和潜在的临床应用。结果肿瘤疫苗旨在激活免疫系统以靶向肿瘤细胞。尽管临床研究仍在进行中，但mRNA疫苗因其灵活性、快速生产和强免疫激活而前景广阔。结论基于疫苗的治疗方法，特别是mRNA疫苗，具有个性化治疗GBM的潜力，但需要进一步的研究来证实疗效并优化使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.