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{"title":"Polyhydroxyalkanoate biopolyesters as extracellular matrix scaffolds by 3D printing technology","authors":"Anuchan Panaksri, Nuttapol Tanadchangsaeng","doi":"10.1002/pi.6740","DOIUrl":null,"url":null,"abstract":"<p>Microbial polyhydroxyalkanoates (PHAs) are biocompatible and biodegradable polyesters synthesized from biomass resources by various microbes in appropriate growth conditions as intracellular energy storage. PHAs have great biocompatibility, low immunological response, bioresorption, non-toxic degradation products and possibly resilient cell adhesion properties. Their mechanical characteristics can be modified to fit numerous tissues ranging from very soft (skin) to hard (bone). Multiple approaches have been used to create well-defined architectures with the best characteristics for processing as medical devices and biomedical application tools. The implementation of PHAs into medical devices as new functional materials with advanced 3D printing techniques has been described. Additionally, new challenges in improving PHA-based bioinks for creating scaffolds with enhanced biodegradation control suitable for tissue regeneration are also elucidated in this review. © 2024 Society of Chemical Industry.</p>","PeriodicalId":20404,"journal":{"name":"Polymer International","volume":"74 10","pages":"874-887"},"PeriodicalIF":3.6000,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer International","FirstCategoryId":"92","ListUrlMain":"https://scijournals.onlinelibrary.wiley.com/doi/10.1002/pi.6740","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
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Abstract
Microbial polyhydroxyalkanoates (PHAs) are biocompatible and biodegradable polyesters synthesized from biomass resources by various microbes in appropriate growth conditions as intracellular energy storage. PHAs have great biocompatibility, low immunological response, bioresorption, non-toxic degradation products and possibly resilient cell adhesion properties. Their mechanical characteristics can be modified to fit numerous tissues ranging from very soft (skin) to hard (bone). Multiple approaches have been used to create well-defined architectures with the best characteristics for processing as medical devices and biomedical application tools. The implementation of PHAs into medical devices as new functional materials with advanced 3D printing techniques has been described. Additionally, new challenges in improving PHA-based bioinks for creating scaffolds with enhanced biodegradation control suitable for tissue regeneration are also elucidated in this review. © 2024 Society of Chemical Industry.
3D打印技术制备聚羟基烷酸生物聚酯细胞外基质支架
微生物聚羟基烷酸酯（PHAs）是一种生物相容性和可生物降解的聚酯，由各种微生物在适当的生长条件下从生物质资源中合成，作为细胞内的能量储存。pha具有良好的生物相容性，低免疫反应，生物再吸收，无毒降解产物和可能具有弹性细胞粘附特性。它们的机械特性可以修改，以适应从非常柔软（皮肤）到坚硬（骨骼）的许多组织。已经使用了多种方法来创建定义良好的体系结构，这些体系结构具有作为医疗设备和生物医学应用工具进行处理的最佳特性。描述了pha作为具有先进3D打印技术的新功能材料在医疗设备中的实施。此外，本文还阐述了pha基生物墨水在制备适合组织再生的具有增强生物降解控制的支架方面所面临的新挑战。©2024化学工业学会。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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