The Impact of LINC-PINT polymorphisms on HNSCC risk in a Chinese han population

IF 2.1 3区生物学 Q2 MULTIDISCIPLINARY SCIENCES

The Science of Nature Pub Date : 2025-09-16 DOI:10.1007/s00114-025-02024-9

Lingyu Kong, Wenjing Wang, Hang Meng, Mengnan Hou, Shan Wang, Wanli Ren, Hao Dai, Bin Li, Tianbo Jin

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Abstract

Head and neck squamous carcinoma (HNSCC) is one of the most common malignant tumors in the upper gastrointestinal tract. Inherited genes are non-modifiable risk factors for HNSCC. This study aims to determine the association between LINC-PINT polymorphism and the risk of HNSCC risk in a Chinese Han population. Genomic DNA was extracted from the whole blood samples of 524 HNSCC patients and 517 healthy controls. The associations of LINC-PINT polymorphisms and HNSCC susceptibility were evaluated through logistic regression analysis. Our study showed that rs157916, rs16873842, and rs7781295 were related to an increased susceptibility to HNSCC. Stratification analyses demonstrated that rs157916 and rs7781295 were associated with an increased risk of HNSCC in age ≤ 46 years, men, and thyroid SCC. Rs16873842 and rs7801029 showed an enhanced risk of HNSCC in men. Additionally, rs16873842 and rs7781295 may increase the risk of Nasopharyngeal SCC. Moreover, the combination of rs7801029 and rs7781295 could serve as a predictive model for HNSCC. This study suggests that LINC-PINT polymorphisms may be correlated with an increased risk of HNSCC.

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LINC-PINT多态性对中国汉族人群HNSCC风险的影响

头颈部鳞状癌（HNSCC）是上消化道最常见的恶性肿瘤之一。遗传基因是HNSCC不可改变的危险因素。本研究旨在确定中国汉族人群中LINC-PINT多态性与HNSCC风险之间的关系。从524例HNSCC患者和517例健康对照者的全血样本中提取基因组DNA。通过logistic回归分析评估LINC-PINT多态性与HNSCC易感性的关系。我们的研究表明rs157916、rs16873842和rs7781295与HNSCC易感性增加有关。分层分析显示rs157916和rs7781295与年龄≤46岁、男性和甲状腺鳞状细胞癌的风险增加相关。Rs16873842和rs7801029在男性中显示出更高的HNSCC风险。此外，rs16873842和rs7781295可能增加鼻咽部SCC的风险。rs7801029和rs7781295组合可作为HNSCC的预测模型。这项研究表明，LINC-PINT多态性可能与HNSCC的风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Science of Nature 综合性期刊-综合性期刊

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Science of Nature - Naturwissenschaften - is Springer''s flagship multidisciplinary science journal. The journal is dedicated to the fast publication and global dissemination of high-quality research and invites papers, which are of interest to the broader community in the biological sciences. Contributions from the chemical, geological, and physical sciences are welcome if contributing to questions of general biological significance. Particularly welcomed are contributions that bridge between traditionally isolated areas and attempt to increase the conceptual understanding of systems and processes that demand an interdisciplinary approach.