Furanone-based comonomer used to manufacture antibacterial bone cement with simultaneously enhanced mechanical strength and antibacterial activity

IF 4.7 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Advances Pub Date : 2025-08-05 DOI:10.1039/D5MA00442J

Xin Wang, Wen-Han Bu, Lu-Yang Han, Long-Xu Han, Qi-Ling Liang, Shan He, Zhe Gao, Yang Xu, Jian-Jun Chu and Fang He

{"title":"Furanone-based comonomer used to manufacture antibacterial bone cement with simultaneously enhanced mechanical strength and antibacterial activity","authors":"Xin Wang, Wen-Han Bu, Lu-Yang Han, Long-Xu Han, Qi-Ling Liang, Shan He, Zhe Gao, Yang Xu, Jian-Jun Chu and Fang He","doi":"10.1039/D5MA00442J","DOIUrl":null,"url":null,"abstract":"Non-leaching bone cement (NLBC) with immobilized antibacterial agents represents a novel approach to fundamentally resolve the issue of burst release of antibiotic-loaded bone cement (ALBC). In this study, a furanone-based methacrylate carbamate comonomer has been reported, which we named FUMA. With this comonomer in hand, a new NLBC FUMA cement was manufactured. Surprisingly, the mechanical strength of the FUMA cement increased with the monomer content, meeting the ISO 5833 requirements. Further studies showed that the antibacterial activity of the FUMA cement increased with higher monomer content, and the 25% FUMA cement exhibited 97.57 ± 2.27% antibacterial activity against Staphylococcus aureus and 43 ± 4.82% against methicillin-resistant Staphylococcus aureus (MRSA). This cement demonstrated no hemolytic activity or acute toxicity. These findings provide new potential approaches for the prevention of periprosthetic joint infections (PJIs).","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 18","pages":" 6406-6415"},"PeriodicalIF":4.7000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00442j?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Advances","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/ma/d5ma00442j","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Non-leaching bone cement (NLBC) with immobilized antibacterial agents represents a novel approach to fundamentally resolve the issue of burst release of antibiotic-loaded bone cement (ALBC). In this study, a furanone-based methacrylate carbamate comonomer has been reported, which we named FUMA. With this comonomer in hand, a new NLBC FUMA cement was manufactured. Surprisingly, the mechanical strength of the FUMA cement increased with the monomer content, meeting the ISO 5833 requirements. Further studies showed that the antibacterial activity of the FUMA cement increased with higher monomer content, and the 25% FUMA cement exhibited 97.57 ± 2.27% antibacterial activity against Staphylococcus aureus and 43 ± 4.82% against methicillin-resistant Staphylococcus aureus (MRSA). This cement demonstrated no hemolytic activity or acute toxicity. These findings provide new potential approaches for the prevention of periprosthetic joint infections (PJIs).

Abstract Image

查看原文本刊更多论文

呋喃酮基共聚体用于制造抗菌骨水泥，同时提高了机械强度和抗菌活性

固定化抗菌剂非溶出骨水泥（NLBC）是一种从根本上解决含抗生素骨水泥（ALBC）爆裂释放问题的新方法。本研究报道了一种呋喃酮基甲基丙烯酸酯氨基甲酸酯共聚体，我们将其命名为fua。有了这种共聚物，一种新的NLBC fua水泥被制造出来。令人惊讶的是，富马水泥的机械强度随着单体含量的增加而增加，符合ISO 5833的要求。进一步研究表明，单体含量越高，fua水泥的抑菌活性越高，25%的fua水泥对金黄色葡萄球菌的抑菌活性为97.57±2.27%，对耐甲氧西林金黄色葡萄球菌（MRSA）的抑菌活性为43±4.82%。这种水泥没有溶血活性或急性毒性。这些发现为预防假体周围关节感染（PJIs）提供了新的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊