Advances in polymeric nanoparticles and hydrogels in 3D bioprinting: Enhancing bioinks for tissue engineering and regenerative medicine

Q1 Computer Science

Bioprinting Pub Date : 2025-09-13 DOI:10.1016/j.bprint.2025.e00438

B. Pavithra , Prabhakar Singh , V Ramesh Kumar , Siva Durairaj , Saqib Hassan

{"title":"Advances in polymeric nanoparticles and hydrogels in 3D bioprinting: Enhancing bioinks for tissue engineering and regenerative medicine","authors":"B. Pavithra , Prabhakar Singh , V Ramesh Kumar , Siva Durairaj , Saqib Hassan","doi":"10.1016/j.bprint.2025.e00438","DOIUrl":null,"url":null,"abstract":"<div><div>In tissue engineering and regenerative medicine, 3D bioprinting has become a revolutionary technique that makes it possible to precisely fabricate intricate biological structures. The creation of sophisticated bioinks, especially those that include hydrogels and polymeric nanoparticles, is essential to its success. These substances promote cellular adhesion, proliferation, and differentiation by providing special physicochemical characteristics that closely resemble the natural extracellular matrix. Hydrogels offer a moist, friendly environment that promotes tissue growth, whereas polymeric nanoparticles improve the mechanical strength, printability, and controlled drug administration of bioinks. Recent developments in the creation and use of hydrogels and polymeric nanoparticles in 3D bioprinting are summarized in this review, with an emphasis on their applications in organ regeneration, wound healing, and personalized medicine<strong>.</strong> It also discusses current problems that need to be resolved in order to transform laboratory breakthroughs into clinical treatments, such as biocompatibility, structural fidelity, and standardization. The future of 3D bioprinting holds the possibility of previously unheard-of advances in functional tissue restoration and patient-specific treatment through the integration of nanotechnology, machine learning, and biomaterial science.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00438"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886625000545","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}

引用次数: 0

Abstract

In tissue engineering and regenerative medicine, 3D bioprinting has become a revolutionary technique that makes it possible to precisely fabricate intricate biological structures. The creation of sophisticated bioinks, especially those that include hydrogels and polymeric nanoparticles, is essential to its success. These substances promote cellular adhesion, proliferation, and differentiation by providing special physicochemical characteristics that closely resemble the natural extracellular matrix. Hydrogels offer a moist, friendly environment that promotes tissue growth, whereas polymeric nanoparticles improve the mechanical strength, printability, and controlled drug administration of bioinks. Recent developments in the creation and use of hydrogels and polymeric nanoparticles in 3D bioprinting are summarized in this review, with an emphasis on their applications in organ regeneration, wound healing, and personalized medicine. It also discusses current problems that need to be resolved in order to transform laboratory breakthroughs into clinical treatments, such as biocompatibility, structural fidelity, and standardization. The future of 3D bioprinting holds the possibility of previously unheard-of advances in functional tissue restoration and patient-specific treatment through the integration of nanotechnology, machine learning, and biomaterial science.

Abstract Image

查看原文本刊更多论文

高分子纳米粒子和水凝胶在3D生物打印中的进展：增强组织工程和再生医学的生物墨水

在组织工程和再生医学领域，生物3D打印已经成为一项革命性的技术，它使精确制造复杂的生物结构成为可能。复杂生物墨水的创造，特别是那些包含水凝胶和聚合纳米颗粒的生物墨水，是其成功的关键。这些物质通过提供与天然细胞外基质非常相似的特殊物理化学特性，促进细胞粘附、增殖和分化。水凝胶提供了一个湿润、友好的环境，促进组织生长，而聚合物纳米颗粒提高了生物墨水的机械强度、可打印性和可控的药物管理。本文综述了水凝胶和聚合物纳米颗粒在生物3D打印中的制备和应用的最新进展，重点介绍了它们在器官再生、伤口愈合和个性化医疗中的应用。它还讨论了当前需要解决的问题，以便将实验室的突破转化为临床治疗，如生物相容性，结构保真度和标准化。通过纳米技术、机器学习和生物材料科学的整合，3D生物打印的未来在功能性组织修复和患者特异性治疗方面拥有前所未有的进步的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioprinting Computer Science-Computer Science Applications

CiteScore

11.50

自引率

0.00%

发文量

审稿时长

68 days

期刊介绍： Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.