Magnolol mitigates morphine-induced analgesic tolerance via EGFR-mediated inhibition of microglial activation and neuroinflammatory reduction

IF 9.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2025-08-15 DOI:10.1016/j.gendis.2025.101802

Weixin Lin , Yuxuan Wang , Qisheng Wang , Jiamin Huang , Ziting Zhou , Yongwei Jiang , Fenfen Qin , Zhonghao Li , Hui Wang , Zijing Wang , Haotian Pan , Qian Wang , Shanzhong Tan , Zhigang Lu

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厚朴酚通过egfr介导的小胶质细胞激活抑制和神经炎症减少来减轻吗啡诱导的镇痛耐受

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.