{"title":"Surface characteristics and biological evaluation of TiO2 nanotubes fabricated on Ti6Al4V implant surface","authors":"Konduru Ashok Kumar Raju, Amit Biswas","doi":"10.1016/j.vacuum.2025.114742","DOIUrl":null,"url":null,"abstract":"<div><div>The significant focus of this research was to create the TiO<sub>2</sub> (Titanium dioxide) highly ordered nanotube arrays on a Ti6Al4V surface to improve surface roughness, antibacterial activity and biocompatibility for its use in biomedical applications. In this approach, the anodic oxidation process was carried out in the organic bath solution, which is composed of ethylene glycol, NH<sub>4</sub>F, and ultrapure water. The process was carried out at a constant voltage of 30 V under different anodic oxidation time durations of 3 h, 4 h, and 5 h. The surface roughness of the polished Ti6Al4V, TiO<sub>2</sub> 30 V 3 h, TiO<sub>2</sub> 30 V 4 h, and TiO<sub>2</sub> 30 V 5 h are 2.77 nm, 16.92 nm, 19.75 nm, and 22.01 nm respectively. The early-stage assessment of the antimicrobial efficacy of oxidized specimens was conducted quantitatively against Bacillus subtilis and Escherichia coli after a 24 h period of growth. The cell viability on different surfaces was investigated by MTT and adhesion assays, which revealed improved in vitro response to the crystalline nanotubes. Overall, this work demonstrates the importance of using multifunctional TiO<sub>2</sub> nanotubes to provide a synergistic impact on antibiofilm, antibacterial, and enhanced osseointegration.</div></div>","PeriodicalId":23559,"journal":{"name":"Vacuum","volume":"242 ","pages":"Article 114742"},"PeriodicalIF":3.9000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vacuum","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0042207X25007328","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The significant focus of this research was to create the TiO2 (Titanium dioxide) highly ordered nanotube arrays on a Ti6Al4V surface to improve surface roughness, antibacterial activity and biocompatibility for its use in biomedical applications. In this approach, the anodic oxidation process was carried out in the organic bath solution, which is composed of ethylene glycol, NH4F, and ultrapure water. The process was carried out at a constant voltage of 30 V under different anodic oxidation time durations of 3 h, 4 h, and 5 h. The surface roughness of the polished Ti6Al4V, TiO2 30 V 3 h, TiO2 30 V 4 h, and TiO2 30 V 5 h are 2.77 nm, 16.92 nm, 19.75 nm, and 22.01 nm respectively. The early-stage assessment of the antimicrobial efficacy of oxidized specimens was conducted quantitatively against Bacillus subtilis and Escherichia coli after a 24 h period of growth. The cell viability on different surfaces was investigated by MTT and adhesion assays, which revealed improved in vitro response to the crystalline nanotubes. Overall, this work demonstrates the importance of using multifunctional TiO2 nanotubes to provide a synergistic impact on antibiofilm, antibacterial, and enhanced osseointegration.
期刊介绍:
Vacuum is an international rapid publications journal with a focus on short communication. All papers are peer-reviewed, with the review process for short communication geared towards very fast turnaround times. The journal also published full research papers, thematic issues and selected papers from leading conferences.
A report in Vacuum should represent a major advance in an area that involves a controlled environment at pressures of one atmosphere or below.
The scope of the journal includes:
1. Vacuum; original developments in vacuum pumping and instrumentation, vacuum measurement, vacuum gas dynamics, gas-surface interactions, surface treatment for UHV applications and low outgassing, vacuum melting, sintering, and vacuum metrology. Technology and solutions for large-scale facilities (e.g., particle accelerators and fusion devices). New instrumentation ( e.g., detectors and electron microscopes).
2. Plasma science; advances in PVD, CVD, plasma-assisted CVD, ion sources, deposition processes and analysis.
3. Surface science; surface engineering, surface chemistry, surface analysis, crystal growth, ion-surface interactions and etching, nanometer-scale processing, surface modification.
4. Materials science; novel functional or structural materials. Metals, ceramics, and polymers. Experiments, simulations, and modelling for understanding structure-property relationships. Thin films and coatings. Nanostructures and ion implantation.