Importance of hematological ratios in dogs with ovarian tumors

IF 2.5 2区农林科学 Q3 REPRODUCTIVE BIOLOGY

Theriogenology Pub Date : 2025-09-11 DOI:10.1016/j.theriogenology.2025.117674

Aslıhan Baykal Uğur , Zeynep Günay Uçmak , Merve Yılmaz , Mert Sarılar , Özge Erdoğan Bamaç , Gülbin Şennazlı , İbrahim Kurban

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Abstract

This study was conducted to evaluate - hematological and biochemical parameters in dogs with ovarian tumors and to compare these findings with those of healthy dogs. Additionally, the differences in platelet-derived markers (platelets (PLT), mean platelet volume (MPV)), hematological ratios, and total blood count parameters between healthy dogs and dogs with ovarian tumors were investigated. Forty-two intact female dogs were included in the study and divided into two groups based on the histopathological examination of the ovaries: the control group (Group C; n = 22), consisting of healthy dogs with no ovarian pathology, and the ovarian tumors group (Group OT; n = 20), consisting of bitches diagnosed with ovarian tumors. Ovarian tumors were classified into two main groups according to the WHO classification of tumors of the genital system of domestic animals: epithelial tumors (Group ET; n = 10) and sex cord-stromal tumors (Group SST; n = 10). Hematological and biochemical analyses were performed using blood samples collected before ovariohysterectomy. Leukocyte count (WBC), neutrophil count (NEU), platelet count (PLT), serum alkaline phosphatase (ALP), and cholesterol (CHOL) levels were found to be significantly higher in Group OT compared to Group C (p < 0.05). Furthermore, WBC, NEU, PLT, ALP, and CHOL values were significantly higher in dogs with epithelial tumors compared to those with sex cord-stromal tumors (p < 0.05). No statistically significant differences were detected in MPV and hematological ratios (NLR, PLR) between the ovarian tumor groups. These findings suggest that ovarian tumors may lead to alterations in hematological and biochemical parameters in dogs, and these changes may vary depending on the tumor type.

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卵巢肿瘤犬血液学比值的重要性

本研究旨在评估卵巢肿瘤犬的血液学和生化参数，并将这些结果与健康犬的结果进行比较。此外，我们还研究了健康犬和卵巢肿瘤犬之间血小板来源标志物（血小板（PLT）、平均血小板体积（MPV））、血液学比率和总血细胞计数参数的差异。选取42只完整雌性犬作为研究对象，根据卵巢的组织病理学检查分为两组：对照组（C组，n = 22），由卵巢无病理的健康犬组成；卵巢肿瘤组（OT组，n = 20），由诊断为卵巢肿瘤的母狗组成。根据WHO对家畜生殖系统肿瘤的分类，将卵巢肿瘤分为上皮性肿瘤（ET组，n = 10）和性索间质肿瘤（SST组，n = 10）两大类。使用卵巢子宫切除术前采集的血液样本进行血液学和生化分析。OT组白细胞计数（WBC）、中性粒细胞计数（NEU）、血小板计数（PLT）、血清碱性磷酸酶（ALP）、胆固醇（CHOL）水平均显著高于C组（p < 0.05）。此外，上皮性肿瘤犬的WBC、NEU、PLT、ALP和CHOL值显著高于性索间质性肿瘤犬（p < 0.05）。卵巢肿瘤组间MPV、血液学比值（NLR、PLR）差异无统计学意义。这些发现表明卵巢肿瘤可能导致狗血液和生化参数的改变，这些变化可能因肿瘤类型而异。

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来源期刊

Theriogenology 农林科学-生殖生物学

CiteScore

5.50

自引率

14.30%

发文量

387

审稿时长

72 days

期刊介绍： Theriogenology provides an international forum for researchers, clinicians, and industry professionals in animal reproductive biology. This acclaimed journal publishes articles on a wide range of topics in reproductive and developmental biology, of domestic mammal, avian, and aquatic species as well as wild species which are the object of veterinary care in research or conservation programs.