Pericardial Disease-Related Mortality in the United States

JACC advances Pub Date : 2025-09-15 DOI:10.1016/j.jacadv.2025.102157

Taimor Mohammed Khan MBBS , Muhammad Moiz Nasir MBBS , Saad Ahmed Waqas MBBS , Muhammad Salik Uddin MBBS , Aymen Ahmed MBBS , Muhammad Omar MBBS , Raheel Ahmed MBBS, PhD , Hasan Fareed Siddiqui MBBS

{"title":"Pericardial Disease-Related Mortality in the United States","authors":"Taimor Mohammed Khan MBBS , Muhammad Moiz Nasir MBBS , Saad Ahmed Waqas MBBS , Muhammad Salik Uddin MBBS , Aymen Ahmed MBBS , Muhammad Omar MBBS , Raheel Ahmed MBBS, PhD , Hasan Fareed Siddiqui MBBS","doi":"10.1016/j.jacadv.2025.102157","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Despite advancements in medical management, pericardial disease (PD)–related mortality is on the rise, yet comprehensive data on its prevalence and mortality rates in the United States remains limited.</div></div><div><h3>Objectives</h3><div>This study aimed to analyze PD-related mortality trends in the United States from 1999 to 2019, focusing on demographic variations based on sex, age, race/ethnicity, geographical regions, and urban–rural distinctions.</div></div><div><h3>Methods</h3><div>A descriptive analysis was conducted using death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Mortality rates were assessed among adults aged ≥25 years diagnosed with PD, using International Classification of Diseases-10th Revision codes. Crude mortality rates and age-adjusted mortality rates (AAMRs) were calculated, and temporal trends were analyzed using joinpoint regression.</div></div><div><h3>Results</h3><div>A total of 87,285 PD-related deaths were recorded during this period. AAMR initially decreased from 2.36 in 1999 to 1.70 in 2012, with an annual percentage change of −2.74% (<em>P</em> < 0.001) However, this trend reversed, as AAMR increased significantly to 2.04 by 2019, with an annual percentage change of +2.94% (<em>P</em> < 0.001). Higher mortality rates were observed among males, older adults (≥65 years), and non-Hispanic Black or African American individuals. The Western region exhibited the highest AAMR, whereas rural areas showed slightly elevated mortality rates compared to urban areas after 2012.</div></div><div><h3>Conclusions</h3><div>These findings underscore a resurgence in PD-related mortality, highlighting the urgent need for improved public health strategies to address this growing burden, particularly among vulnerable populations.</div></div>","PeriodicalId":73527,"journal":{"name":"JACC advances","volume":"4 10","pages":"Article 102157"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JACC advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772963X25005824","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Despite advancements in medical management, pericardial disease (PD)–related mortality is on the rise, yet comprehensive data on its prevalence and mortality rates in the United States remains limited.

Objectives

This study aimed to analyze PD-related mortality trends in the United States from 1999 to 2019, focusing on demographic variations based on sex, age, race/ethnicity, geographical regions, and urban–rural distinctions.

Methods

A descriptive analysis was conducted using death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Mortality rates were assessed among adults aged ≥25 years diagnosed with PD, using International Classification of Diseases-10th Revision codes. Crude mortality rates and age-adjusted mortality rates (AAMRs) were calculated, and temporal trends were analyzed using joinpoint regression.

Results

A total of 87,285 PD-related deaths were recorded during this period. AAMR initially decreased from 2.36 in 1999 to 1.70 in 2012, with an annual percentage change of −2.74% (P < 0.001) However, this trend reversed, as AAMR increased significantly to 2.04 by 2019, with an annual percentage change of +2.94% (P < 0.001). Higher mortality rates were observed among males, older adults (≥65 years), and non-Hispanic Black or African American individuals. The Western region exhibited the highest AAMR, whereas rural areas showed slightly elevated mortality rates compared to urban areas after 2012.

Conclusions

These findings underscore a resurgence in PD-related mortality, highlighting the urgent need for improved public health strategies to address this growing burden, particularly among vulnerable populations.

查看原文本刊更多论文

美国心包疾病相关死亡率

背景：尽管医疗管理取得了进步，但心包疾病（PD）相关的死亡率正在上升，但有关其患病率和死亡率的综合数据在美国仍然有限。本研究旨在分析1999年至2019年美国pd相关死亡率趋势，重点关注基于性别、年龄、种族/民族、地理区域和城乡差异的人口统计学变化。方法采用美国疾病控制与预防中心流行病学研究在线数据数据库中的死亡证明数据进行描述性分析。使用国际疾病分类第10版代码评估年龄≥25岁诊断为PD的成年人的死亡率。计算粗死亡率和年龄调整死亡率（AAMRs），并使用联结点回归分析时间趋势。结果在此期间共记录了87285例pd相关死亡。AAMR最初从1999年的2.36下降到2012年的1.70，年百分比变化为- 2.74% (P < 0.001)，但这一趋势发生逆转，到2019年，AAMR显著上升至2.04，年百分比变化为+2.94% （P < 0.001）。男性、老年人（≥65岁）和非西班牙裔黑人或非洲裔美国人的死亡率较高。2012年后，西部地区的AAMR最高，而农村地区的死亡率略高于城市地区。这些发现强调了pd相关死亡率的复苏，强调了改善公共卫生策略以解决这一日益增长的负担的迫切需要，特别是在弱势群体中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

JACC advances Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量