Tailoring of magnetic β-cyclodextrin-based nanogels via gamma irradiation: Structural characterization and anticancer efficacy

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Asmaa Sayed , Amal Shawky , Ibrahim E. El-Sayed , Ghada A. Mahmoud
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Abstract

Targeted drug delivery systems that combine therapeutic efficiency with fewer side effects are highly promoted in cancer treatment. In this study, multifunctional CoFe2O4@DEX/PNIPAm nanogels were synthesized through gamma irradiation-induced copolymerization of β-cyclodextrin-modified dextrin (DEX) and N-isopropylacrylamide (NIPAm), followed by the addition of magnetic cobalt ferrite CoFe2O4 nanoparticles. The eco-friendly, initiator-free method ensures biocompatibility and environmental safety. Structural (FTIR, XRD) and morphological (TEM, SEM, AFM) analyses confirmed a semi-amorphous nanogel matrix with evenly distributed crystalline nanoparticles, exhibiting increased compactness and altered surface topography at higher irradiation doses. Elemental analysis (EDX and mapping) verified the uniform distribution of Co and Fe within the nanogel. Magnetic measurements indicated soft ferromagnetic behavior where saturation magnetization Ms = 4.16 emu/g and coercivity Hci = 89.5 G, enabling potential magnetic guidance. Functionally, the nanogels demonstrated dose-dependent antibacterial activity against Enterococci and Klebsiella, as well as selective toxicity toward colon cancer cells, with minimal effects on normal fibroblasts (WI-38). These findings suggest CoFe2O4@DEX/PNIPAm nanogels as a promising, magnetically responsive, and biocompatible platform for targeted anticancer therapy and antimicrobial applications, offering a green nanomaterial alternative to conventional treatments.

Abstract Image

磁β-环糊精基纳米凝胶的γ辐照剪裁:结构表征和抗癌功效
靶向药物输送系统结合了治疗效率和较少的副作用,在癌症治疗中得到高度推广。在本研究中,通过γ辐照诱导β-环糊精修饰的糊精(DEX)和n-异丙基丙烯酰胺(NIPAm)共聚,然后加入磁性钴铁氧体CoFe2O4纳米颗粒,合成了多功能CoFe2O4@DEX/PNIPAm纳米凝胶。生态友好,无引发剂的方法确保生物相容性和环境安全性。结构(FTIR, XRD)和形貌(TEM, SEM, AFM)分析证实了半无定形纳米凝胶基质具有均匀分布的晶体纳米颗粒,在高辐照剂量下表现出致密性增加和表面形貌改变。元素分析(EDX和绘图)证实了Co和Fe在纳米凝胶中的均匀分布。磁测量表明,饱和磁化Ms = 4.16 emu/g,矫顽力Hci = 89.5 g,具有软铁磁特性,实现了电位磁制导。在功能上,纳米凝胶对肠球菌和克雷伯氏菌具有剂量依赖性的抗菌活性,对结肠癌细胞具有选择性毒性,对正常成纤维细胞的影响最小(WI-38)。这些发现表明CoFe2O4@DEX/PNIPAm纳米凝胶是一种有前景的、具有磁响应性和生物相容性的靶向抗癌治疗和抗菌应用平台,为传统治疗提供了一种绿色纳米材料替代方案。
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来源期刊
CiteScore
8.00
自引率
8.00%
发文量
879
审稿时长
94 days
期刊介绍: The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.
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