In situ tissue stiffening as a model of early lung injury and disease

IF 38.5 1区材料科学 Q1 CHEMISTRY, PHYSICAL

Nature Materials Pub Date : 2025-09-15 DOI:10.1038/s41563-025-02337-0

引用次数: 0

Abstract

Extracellular matrix remodelling and densification are hallmarks of fibrosis that have been challenging to study ex vivo. Visible light-induced dityrosine crosslinking of native matrix proteins in viable lung tissues has now been shown to recapitulate local stiffening that characterizes early lung injury. This stiffening led to aberrant alveolar epithelial cell differentiation, mechanosensing and nascent protein deposition.

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原位组织硬化作为早期肺损伤和疾病的模型

细胞外基质重塑和致密化是纤维化的标志，体外研究一直具有挑战性。可见光诱导的原生基质蛋白在活肺组织中的二酪氨酸交联现在已被证明再现了早期肺损伤特征的局部硬化。这种硬化导致异常的肺泡上皮细胞分化、机械感应和新生蛋白沉积。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Materials 工程技术-材料科学：综合

CiteScore

62.20

自引率

0.70%

发文量

221

审稿时长

3.2 months

期刊介绍： Nature Materials is a monthly multi-disciplinary journal aimed at bringing together cutting-edge research across the entire spectrum of materials science and engineering. It covers all applied and fundamental aspects of the synthesis/processing, structure/composition, properties, and performance of materials. The journal recognizes that materials research has an increasing impact on classical disciplines such as physics, chemistry, and biology. Additionally, Nature Materials provides a forum for the development of a common identity among materials scientists and encourages interdisciplinary collaboration. It takes an integrated and balanced approach to all areas of materials research, fostering the exchange of ideas between scientists involved in different disciplines. Nature Materials is an invaluable resource for scientists in academia and industry who are active in discovering and developing materials and materials-related concepts. It offers engaging and informative papers of exceptional significance and quality, with the aim of influencing the development of society in the future.