Maohu Wang , Xiaowei Xun , Shiqing Zhou , Dingyun Wang , Dongxue Zhang , Xidong Wu , Yacao Ying , Haiyong Ao
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引用次数: 0
Abstract
Resveratrol (RES) exhibits a wide range of pharmacological activities, including antibacterial, anti-inflammatory, and antioxidant properties, making it a promising candidate for improving the multifunctionality of bacterial cellulose (BC)-based dressings. Nevertheless, the low water solubility and poor stability of RES have significantly limited its bioavailability. Herein, bioactive glass (BG) with good biological properties and drug loading capacity was used as a medium to introduce RES into the BC network structure, and a novel RES-loaded BG modified BC (RES@BG-BC) dressing was developed by using the sol-gel synthesis and hydrolysis reaction. Results of characterization confirmed successful construction of RES@BG coating on the surface of BC nanofibers with nanoporous network. The obtained RES@BG-BC exhibited favorable thermostability, fast water absorption and enhanced mechanical properties. Notably, RES@BG-BC exhibits a superior sustained release capacity of RES (continuous release for 120 h) and achieves a higher cumulative release amount (133.70 ± 1.84 μmol/L) compared to RES@BC. Importantly, the introduction of RES endowed the BC-based dressing with favorable broad-spectrum antibacterial properties, excellent antioxidation and anti-inflammatory properties. While the promotion of the NIH3T3 proliferation, HUVECs migration and the VEGF secretion was attributed to the synergistic effect of RES and BG. These findings illustrate that the developed RES@BG-BC dressing hold significant therapeutic potential in wound treatment, and offer a novel strategy for incorporating BC with Chinese herbal extracts.
期刊介绍:
Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics.
The main scope is covered but not limited to the following core areas:
Polymer Materials
Nanocomposites and hybrid nanomaterials
Polymer blends, films, fibres, networks and porous materials
Physical Characterization
Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films
Polymer Engineering
Advanced multiscale processing methods
Polymer Synthesis, Modification and Self-assembly
Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization
Technological Applications
Polymers for energy generation and storage
Polymer membranes for separation technology
Polymers for opto- and microelectronics.