Mechanisms of tumor aggressiveness driven by ablation-induced niche remodeling

Abstract

Tumor niche represents a dynamic, functionally specialized microenvironment defined by reciprocal interactions between tumor cells and their surrounding stroma. However, emerging evidence suggests that ablation-induced niche remodeling may promote tumor aggressiveness, counteracting therapeutic benefits. This review summarizes current insights into the role of ablation-induced niche remodeling in tumor progression. We begin with a bibliometric analysis to illustrate research trends and identify the hotspots. We then explore the underlying biological mechanisms of niche remodeling post-ablation, with a focus on three key aspects: resistance to cell death, immune cell reprogramming toward immunosuppression, and enhanced tumor invasiveness and migration. These insights may inform future research directions and support the development of more effective clinical strategies.