Targeting BCMA in CIDP: Valuable insights gained through multi-omics immune monitoring.

IF 11.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-09-12 DOI:10.1016/j.medj.2025.100753

Maximilian A Funk, Sebastian Theurich

引用次数: 0

Abstract

Dong et al. present two patients with refractory chronic inflammatory demyelinating polyneuropathy (CIDP), who received treatment with B-cell-maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cells.¹ Extensive concomitant immune monitoring provides insights into the pathogenesis and mechanisms of relapse in CIDP that may help to determine the role of BCMA-targeted CAR-T cell therapy for this disease in the future.

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靶向BCMA在CIDP：通过多组学免疫监测获得有价值的见解。

Dong等报道了两例难治性慢性炎症性脱髓鞘性多神经病变（CIDP）患者，他们接受了b细胞成熟抗原（BCMA）靶向嵌合抗原受体(CAR)-T细胞的治疗广泛的伴随免疫监测提供了对CIDP发病机制和复发机制的见解，这可能有助于确定bcma靶向CAR-T细胞治疗在未来对该疾病的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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