Effects of Improved Sleep and Gastric Vagotomy on Serum Inflammatory Mediators in Peptic Ulcer Rats.

IF 2.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurogastroenterology and Motility Pub Date : 2025-09-13 DOI:10.1111/nmo.70136

Huang Du, Lianxiang Peng, Guohua Gong, Shuping Xiao, Rongpan Lin, Kangming Huang, Mingxia Wu, Nating Wei, Wangfeng Cai, Hongbin Chen

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引用次数: 0

Abstract

Objective: Vagotomy is a method used to treat peptic ulcers, but its mechanism of action in terms of inflammatory mediators and neurophysiology remains unclear. This study investigates the effects of vagotomy and improved sleep on serum inflammatory mediators in rats.

Methods: One hundred and eighty healthy rats were allocated into five groups, each consisting of 36 rats: control, sleep disturbance, ulcer, improved sleep and vagotomy. They underwent various treatments, including sleep deprivation, ulcer induction with acetic acid, and vagotomy. We measured gastric vagal nerve activity, gastric acid secretion, and serum inflammatory mediators (IL-1β, IL-6, IL-8, TNF-α), comparing these parameters across groups.

Results: Gastric acid secretion was elevated in the sleep disturbance and ulcer group but decreased in the improved sleep group (p < 0.01). Gastric vagal nerve activity was heightened in the sleep disturbance and ulcer group, with some improvement in the improved sleep group. Serum inflammatory mediators' mRNA expression was increased in both the ulcer and sleep disturbance group, while it decreased in the improved sleep and vagotomy group (p < 0.01). The vagotomy group showed no significant inflammation in the gastric mucosa, while some recovery was observed in the ulcer area's mucosa in the improved sleep group.

Conclusion: Improved sleep can enhance vagal nerve excitability, decrease inflammatory mediator release, and support the healing of peptic ulcers.

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改善睡眠和胃迷走神经切断术对消化性溃疡大鼠血清炎症介质的影响。

目的：迷走神经切开术是一种治疗消化性溃疡的方法，但其在炎症介质和神经生理学方面的作用机制尚不清楚。本研究探讨迷走神经切断术和改善睡眠对大鼠血清炎症介质的影响。方法：将健康大鼠180只分为5组，每组36只：对照组、睡眠障碍组、溃疡组、改善睡眠组和迷走神经切开术组。他们接受了各种治疗，包括剥夺睡眠、醋酸诱导溃疡和迷走神经切开术。我们测量了胃迷走神经活动、胃酸分泌和血清炎症介质（IL-1β、IL-6、IL-8、TNF-α），比较各组间的这些参数。结果：睡眠障碍组和溃疡组胃酸分泌升高，改善睡眠组胃酸分泌降低(p)。结论：改善睡眠可增强迷走神经兴奋性，减少炎症介质释放，支持消化性溃疡的愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.