Corticotropin-releasing hormone signaling from piriform cortex to amygdala mediates social homophily in opioid addiction.

IF 15 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-09-09 DOI:10.1016/j.neuron.2025.08.012

Yu Huo, Xingyuan Wang, Xiaorui Lin, Jiaojiao Yu, Binlong Li, Zepeng Liu, Shengyang Guo, Yutong Wang, Rongchun Tang, Bofei Li, Shunjie Zhang, Yunke Zhang, Zhehan Jiang, Xiang Fan, Xinzhi Ye, Yifan Li, Xinyu Zhang, Yun Yao, Sen Song, Mao Xu, Hong Jiang, Guogang Xing, You Wan, Cailian Cui, Yijing Li, Linlin Sun

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引用次数: 0

Abstract

Social partner selection can significantly influence one's social well-being, emotional support, and even cognitive functions. Drug-abstinent mice exhibit sociability deficits, yet how drug-addicted individuals select their social partners and how these choices influence addiction-related behaviors remain unclear. In this study, we demonstrate that opioid-experienced mice prefer socializing with opioid-experienced peers. Presentation of an opioid-abstinent demonstrator mouse or its olfactory cues (not ultrasound or visual cues) enhances corticotropin-releasing hormone (CRH) release from the anterior piriform cortex (APIR) to the basomedial amygdala (BMA) in abstinent observer mice. This CRH release occurs specifically during approach, acts through CRH receptor 1/2 in the BMA, and enhances social motivation. Disruption of this social homophily impairs addiction-related memory and relapse in opioid-abstinent mice. Our findings reveal social homophily in opioid-experienced individuals, elucidate the underlying APIR-BMA CRH signaling mechanism, and underscore the importance of social support from non-addicted peers for opioid-abstinent individuals during recovery.

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从梨状皮质到杏仁核的促肾上腺皮质激素释放激素信号介导阿片类药物成瘾的社会同质性。

社会伴侣选择可以显著影响一个人的社会幸福感、情感支持甚至认知功能。戒毒小鼠表现出社交缺陷，然而吸毒成瘾个体如何选择他们的社会伙伴以及这些选择如何影响成瘾相关行为仍不清楚。在这项研究中，我们证明了有阿片类药物经验的小鼠更喜欢与有阿片类药物经验的同伴交往。展示阿片类药物戒断示范小鼠或其嗅觉线索（不是超声或视觉线索）可增强戒断观察小鼠从前梨状皮质（APIR）向基底内侧杏仁核（BMA）释放促肾上腺皮质激素（CRH）。这种CRH释放在接近过程中特异性发生，通过BMA中的CRH受体1/2起作用，并增强社交动机。这种社会同质性的破坏会损害阿片类药物戒断小鼠的成瘾相关记忆和复发。我们的研究结果揭示了阿片类药物经历个体的社会同质性，阐明了潜在的APIR-BMA CRH信号机制，并强调了非成瘾同伴的社会支持对阿片类药物戒断个体在康复过程中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.