Phase angle as a predictor of complications in acute stroke: A cohort study

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-09-11 DOI:10.1016/j.clnesp.2025.09.004

Keisuke Honma , Tomoyuki Ogino , Koichiro Sota , Naoki Sasanuma , Masataka Igeta , Yuki Uchiyama , Kazuhisa Domen

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引用次数: 0

Abstract

Background and aims

Complications following acute stroke can worsen prognosis. Skeletal muscle mass and quality may influence these outcomes. To investigate the association between skeletal muscle quantity and quality with the incidence of complications in patients hospitalized for acute stroke.

Methods and results

This single center prospective cohort study evaluated 646 consecutive patients who were hospitalized for acute stroke (women: 45 %, hemorrhagic stroke: 20 %). The main study outcome was the occurrence of complications during acute hospitalization. Skeletal muscle mass and quality were assessed via bioelectrical impedance analysis, with skeletal muscle index (SMI) representing mass and phase angle (PhA) reflecting quality. A binary logistic regression analysis was performed to determine the factors that were associated with the occurrence of complications upon admission. A total of 179 patients (27.7 %) experienced complications. These individuals were significantly older, had lower body mass index, higher NIH Stroke Scale (NIHSS) scores, and poorer nutritional status. Multivariate analysis showed that higher NIHSS (OR 1.10, 95 % CI 1.08–1.13, p = 0.001), older age (OR 1.03, 95 % CI 1.00–1.05, p = 0.030), and lower PhA (OR 0.74, 95 % CI 0.57–0.97, p = 0.028) were independently associated with complications. SMI was not a significant predictor.

Conclusions

PhA was independently associated with the occurrence of complications during acute hospitalization. Moreover, its evaluation in acute stroke is noninvasive and easy to perform, potentially enabling early prediction of complications.

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相位角作为急性卒中并发症的预测因子：一项队列研究。

背景和目的：急性脑卒中并发症可使预后恶化。骨骼肌的质量和质量可能影响这些结果。探讨急性脑卒中住院患者骨骼肌数量和质量与并发症发生率的关系。方法和结果：这项单中心前瞻性队列研究评估了646例因急性卒中住院的连续患者（女性：45%，出血性卒中：20%）。主要研究结果为急性住院期间并发症的发生情况。通过生物电阻抗分析评估骨骼肌质量和质量，骨骼肌指数（SMI）代表质量，相位角（PhA）反映质量。采用二元logistic回归分析确定与入院时并发症发生相关的因素。179例（27.7%）出现并发症。这些个体明显年龄较大，体重指数较低，NIH卒中量表（NIHSS）评分较高，营养状况较差。多因素分析显示，较高的NIHSS （OR 1.10, 95% CI 1.08-1.13, p = 0.001）、较大的年龄（OR 1.03, 95% CI 1.00-1.05, p = 0.030）和较低的PhA （OR 0.74, 95% CI 0.57-0.97, p = 0.028）与并发症独立相关。重度精神分裂症并不是一个显著的预测因子。结论：PhA与急性住院期间并发症的发生独立相关。此外，它在急性脑卒中中的评估是非侵入性的，易于执行，有可能早期预测并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.