The acute effects of alpha-lactalbumin intake on tryptophan metabolites and mood in older adults with Mild Cognitive Impairment.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2025-09-14 DOI:10.1080/1028415X.2025.2554359

Arion K Yu, Nicolaas E P Deutz, Carolina N Perez, Sofie DeWandel, Laura E Ruebush, Mariëlle P K J Engelen

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引用次数: 0

Abstract

Objective: This study explores the relationship between Mild Cognitive Impairment (MCI), mood disturbances, and tryptophan (TRP) metabolites of the kynurenine and serotonin pathway in older adults, focusing on the acute effects of a TRP-rich protein meal.

Methods: 32 older adults (age 55 and up) with MCI (MoCA score 18-26) and 26 older adults without MCI matched for age, sex, and body mass index (BMI) were assessed for mood and TRP metabolites. A subset of these subjects then consumed an alpha-lactalbumin (ALAC) meal rich in TRP. Plasma TRP metabolite concentrations and mood (using the Profile of Mood States (POMS) scale) were assessed before and 3 h after intake.

Results: At baseline, MCI subjects had higher plasma anthranilic acid than non-MCI controls (p = 0.015). Intake of ALAC resulted in increases in plasma TRP, kynurenine, 3-hydroxykynurenine, kynurenic acid, picolinic acid (all p < 0.001), and anthranilic acid (p = <0.001) but not in serotonin (p = 0.065). Higher picolinic acid levels were found after ALAC intake in the MCI than in the non-MCI group (p = <0.001). The TRP/large neutral amino acid ratio increased by 89.9% in MCI subjects and 95.9% in controls. There were no acute changes in mood after ALAC intake.

Discussion: Older adults with MCI showed elevated baseline anthranilic acid, and TRP-rich protein intake acutely increases TRP availability and upregulates the kynurenine but not serotonin pathway without mood improvement. Post-ALAC increases in picolinic acid in MCI subjects warrants further investigation.Trial registration: ClinicalTrials.gov identifiers: NCT05395390, NCT02082418.

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α -乳清蛋白摄入对老年轻度认知障碍患者色氨酸代谢产物和情绪的急性影响。

目的：本研究探讨老年人轻度认知障碍（MCI）、情绪障碍与犬尿氨酸和血清素途径中色氨酸（TRP）代谢物之间的关系，重点研究富含TRP的蛋白餐的急性作用。方法：对32名年龄在55岁及以上的轻度认知损伤老年人（MoCA评分18-26）和26名年龄、性别和体重指数（BMI）相匹配的非轻度认知损伤老年人进行情绪和TRP代谢物评估。然后，这些受试者中的一部分人食用了富含色氨酸的α -乳清蛋白（ALAC）餐。血浆TRP代谢物浓度和情绪（使用心境状态量表（POMS））在摄入前和摄入后3小时进行评估。结果：在基线时，MCI受试者的血浆邻氨基苯酸高于非MCI对照组（p = 0.015）。摄入ALAC导致血浆TRP、犬尿氨酸、3-羟基犬尿氨酸、犬尿酸、吡啶酸升高（均p = p = 0.065）。与非MCI组相比，MCI患者在摄入ALAC后发现吡啶酸水平更高(p =讨论：患有MCI的老年人显示基线氨基苯酸升高，富含TRP的蛋白质摄入会急剧增加TRP的可用性，上调犬尿氨酸，但没有改善情绪的血清素途径。MCI患者alac后吡啶酸升高值得进一步研究。试验注册：ClinicalTrials.gov标识符：NCT05395390， NCT02082418。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.