Social interaction deficits and anxiety-like behavioral changes in the TgF344-AD rat model of Alzheimer's disease

IF 2.3 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-09-11 DOI:10.1016/j.bbr.2025.115820

Daniela Černotová , Kristýna Malenínská , Anna Horáková , Veronika Rudolfová , Aleš Stuchlík , Jan Svoboda

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引用次数: 0

Abstract

Alzheimer's disease (AD) is often accompanied by neuropsychiatric symptoms, which may manifest as anxiety, decreased initiative, and social withdrawal. The TgF344-AD rat model recapitulates several AD-like pathological features and cognitive deficits, yet the progression of anxiety-like and social behavior impairments remains poorly characterized. In this study, we investigated anxiety-like and social behaviors in male and female TgF344-AD rats at 10 and 14 months of age using the open field, elevated plus-maze, and social interaction paradigms. While standard anxiety measures showed limited genotype effects, we observed decreased exploratory behaviors in male rats across the experimental setups. Importantly, notable social interaction deficits were identified in TgF344-AD rats, persisting across both age points. Our behavioral assessment provides an essential characterization of this model in the mid-stage disease when neuropathological changes and cognitive symptoms are developed. Most importantly, this work provides evidence for social behavior deficits in the TgF344-AD model and contributes to understanding non-cognitive changes in AD.

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阿尔茨海默病TgF344-AD大鼠模型的社会互动缺陷和焦虑样行为改变

阿尔茨海默病（AD）常伴有神经精神症状，表现为焦虑、主动性下降和社交退缩。TgF344-AD大鼠模型概括了几种ad样病理特征和认知缺陷，但焦虑样和社交行为障碍的进展仍然缺乏特征。在本研究中，我们采用开放场、高架+迷宫和社会互动范式研究了10和14月龄雄性和雌性TgF344-AD大鼠的焦虑样行为和社交行为。虽然标准焦虑测量显示有限的基因型效应，但我们观察到在整个实验设置中，雄性大鼠的探索行为减少。重要的是，在TgF344-AD大鼠中发现了显著的社会互动缺陷，持续存在于两个年龄点。当神经病理改变和认知症状出现时，我们的行为评估提供了该模型在疾病中期的基本特征。最重要的是，这项工作为TgF344-AD模型中的社会行为缺陷提供了证据，并有助于理解AD的非认知变化。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.