{"title":"Nickel-Catalyzed Hydrogenation and Dehydrogenation Processes: A Useful Tool in Organic Synthesis","authors":"Rahul Paul, Sk Shamim Ahamed, Tapas Ghosh","doi":"10.1002/ajoc.202500069","DOIUrl":null,"url":null,"abstract":"<p>Catalytic hydrogenation and dehydrogenation are fundamental transformations in organic synthesis, traditionally dominated by noble metals. In recent decades, nickel has emerged as a sustainable and cost-effective alternative due to its rich redox chemistry, broad applicability, and catalytic efficiency. This review comprehensively summarizes the progress in nickel-catalyzed hydrogenation and dehydrogenation reactions over the past three decades, emphasizing the evolution of catalyst design and mechanistic understanding as well. This review is structured into three major categories based on catalyst type: homogeneous, heterogeneous, and nanoparticle-supported catalyst. Each section is further divided into direct hydrogenation, transfer hydrogenation, and dehydrogenation reactions, covering a wide range of substrates including alkynes, alkenes, carbonyl compounds, nitroarenes, amines, and alcohols. Structure–activity relationships, mechanistic pathways, and chemoselectivity trends are critically analyzed to provide insights into the role of nickel in these transformations. Challenges and future directions in developing next-generation nickel catalysts for green and selective transformations are also outlined.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500069","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Catalytic hydrogenation and dehydrogenation are fundamental transformations in organic synthesis, traditionally dominated by noble metals. In recent decades, nickel has emerged as a sustainable and cost-effective alternative due to its rich redox chemistry, broad applicability, and catalytic efficiency. This review comprehensively summarizes the progress in nickel-catalyzed hydrogenation and dehydrogenation reactions over the past three decades, emphasizing the evolution of catalyst design and mechanistic understanding as well. This review is structured into three major categories based on catalyst type: homogeneous, heterogeneous, and nanoparticle-supported catalyst. Each section is further divided into direct hydrogenation, transfer hydrogenation, and dehydrogenation reactions, covering a wide range of substrates including alkynes, alkenes, carbonyl compounds, nitroarenes, amines, and alcohols. Structure–activity relationships, mechanistic pathways, and chemoselectivity trends are critically analyzed to provide insights into the role of nickel in these transformations. Challenges and future directions in developing next-generation nickel catalysts for green and selective transformations are also outlined.
期刊介绍:
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.