Nickel-Catalyzed Hydrogenation and Dehydrogenation Processes: A Useful Tool in Organic Synthesis

IF 2.7 4区 化学 Q1 CHEMISTRY, ORGANIC
Rahul Paul, Sk Shamim Ahamed, Tapas Ghosh
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引用次数: 0

Abstract

Catalytic hydrogenation and dehydrogenation are fundamental transformations in organic synthesis, traditionally dominated by noble metals. In recent decades, nickel has emerged as a sustainable and cost-effective alternative due to its rich redox chemistry, broad applicability, and catalytic efficiency. This review comprehensively summarizes the progress in nickel-catalyzed hydrogenation and dehydrogenation reactions over the past three decades, emphasizing the evolution of catalyst design and mechanistic understanding as well. This review is structured into three major categories based on catalyst type: homogeneous, heterogeneous, and nanoparticle-supported catalyst. Each section is further divided into direct hydrogenation, transfer hydrogenation, and dehydrogenation reactions, covering a wide range of substrates including alkynes, alkenes, carbonyl compounds, nitroarenes, amines, and alcohols. Structure–activity relationships, mechanistic pathways, and chemoselectivity trends are critically analyzed to provide insights into the role of nickel in these transformations. Challenges and future directions in developing next-generation nickel catalysts for green and selective transformations are also outlined.

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镍催化的加氢和脱氢过程:有机合成中的一个有用工具
催化加氢和脱氢是有机合成中的基本转化,传统上以贵金属为主。近几十年来,镍因其丰富的氧化还原化学性质、广泛的适用性和催化效率而成为一种可持续的、具有成本效益的替代品。本文综述了近三十年来镍催化加氢和脱氢反应的研究进展,重点介绍了镍催化加氢和脱氢反应的催化剂设计和机理的研究进展。本综述根据催化剂类型分为三大类:均相、非均相和纳米颗粒负载型催化剂。每一部分又进一步分为直接加氢、转移加氢和脱氢反应,涵盖了广泛的底物,包括炔烃、烯烃、羰基化合物、硝基芳烃、胺和醇。结构-活性关系,机制途径和化学选择性趋势进行了批判性分析,以提供对镍在这些转化中的作用的见解。展望了下一代镍催化剂在绿色转化和选择性转化方面面临的挑战和未来发展方向。
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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