Catalytic Ullmann-Type N-Arylation to Access Medicinally Important SuFEx-able Pyrazolo[1,5-a]Quinoxalinones

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-10 DOI:10.1002/ajoc.202500474

Bipin Khanal, Kanokwan Jaithum, Mark Aldren M Feliciano, Brian Gold

引用次数: 0

Abstract

Pyrazole-fused quinoxalines provide an attractive structural motif for medicinal chemistry and have inspired the development of novel synthetic methods. This work details a concise methodology for the synthesis of a new class of pyrazolo[1,5-a]quinoxaline-4-ones, where the incorporation of a sulfonyl fluoride enables sulfur(IV) fluoride exchange (SuFEx) chemistry. This synthetic approach opens the door for the rapid diversification of these fused heterocycles, providing a powerful strategy for the expansion of chemical space and the development of novel bioactive compounds.

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催化ullmann -型n-芳基化制备具有药用意义的吡唑啉[1,5-a]喹诺沙林酮

吡唑-融合喹诺啉为药物化学提供了一个有吸引力的结构基序，并激发了新的合成方法的发展。这项工作详细介绍了合成一类新的吡唑啉[1,5-a]喹诺啉-4- 1的简明方法，其中加入磺酰氟可以实现硫（IV）氟交换（SuFEx）化学。这种合成方法为这些融合杂环的快速多样化打开了大门，为扩大化学空间和开发新的生物活性化合物提供了强有力的策略。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.