Advancement in the Synthetic Methodologies for C─O and C─S Cross-Coupling Reactions via Homogeneous Catalysis: A Decade of Progress

IF 2.7 4区 化学 Q1 CHEMISTRY, ORGANIC
Eden Sinchana D Souza, Sumanth Hegde, Aatika Nizam, Vasantha Veerappa Lakshmaiah
{"title":"Advancement in the Synthetic Methodologies for C─O and C─S Cross-Coupling Reactions via Homogeneous Catalysis: A Decade of Progress","authors":"Eden Sinchana D Souza,&nbsp;Sumanth Hegde,&nbsp;Aatika Nizam,&nbsp;Vasantha Veerappa Lakshmaiah","doi":"10.1002/ajoc.202500266","DOIUrl":null,"url":null,"abstract":"<p>Carbon-heteroatom coupling reactions are a very crucial category of transformations in organic synthesis, enabling the creation of a wide range of chemical structures essential for pharmaceuticals, agrochemicals, and material science. These reactions involve the formation of a bond between carbon and heteroatoms such as nitrogen, sulfur, and oxygen, which play a vital role in the functionalization of organic molecules. Various pharmaceutical drug molecules have a carbon-heteroatom bond as the core component. Therefore, the synthesis of such molecules has garnered considerable attention in recent years. This review explores advancements in methodologies and catalytic systems that promote C─X (where X = O, S) bond formation, with a focus on cross-coupling reactions involving sulfur and oxygen. We highlight the development of different novel catalysts, transition metals, transition metal-free methods, and different sulfur and oxygen sources used for this conversion that provided greater efficiency, selectivity, and functional group tolerance over the decade (2014–2024). Also, this review aims to provide the current trends as well as the future scope in carbon-heteroatom coupling reactions.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500266","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0

Abstract

Carbon-heteroatom coupling reactions are a very crucial category of transformations in organic synthesis, enabling the creation of a wide range of chemical structures essential for pharmaceuticals, agrochemicals, and material science. These reactions involve the formation of a bond between carbon and heteroatoms such as nitrogen, sulfur, and oxygen, which play a vital role in the functionalization of organic molecules. Various pharmaceutical drug molecules have a carbon-heteroatom bond as the core component. Therefore, the synthesis of such molecules has garnered considerable attention in recent years. This review explores advancements in methodologies and catalytic systems that promote C─X (where X = O, S) bond formation, with a focus on cross-coupling reactions involving sulfur and oxygen. We highlight the development of different novel catalysts, transition metals, transition metal-free methods, and different sulfur and oxygen sources used for this conversion that provided greater efficiency, selectivity, and functional group tolerance over the decade (2014–2024). Also, this review aims to provide the current trends as well as the future scope in carbon-heteroatom coupling reactions.

Abstract Image

Abstract Image

Abstract Image

均相催化下C─O和C─S交叉偶联反应合成方法的进展:十年的进展
碳杂原子偶联反应是有机合成中一个非常重要的转化类别,它能够创造出广泛的化学结构,这些结构对制药、农用化学品和材料科学至关重要。这些反应涉及碳和杂原子(如氮、硫和氧)之间形成键,这在有机分子的功能化中起着至关重要的作用。各种药物分子都有一个碳杂原子键作为核心成分。因此,近年来这类分子的合成受到了相当大的关注。本文综述了促进C─X(其中X = O, S)键形成的方法和催化系统的进展,重点是涉及硫和氧的交叉偶联反应。我们重点介绍了在过去十年(2014-2024)中,不同新型催化剂、过渡金属、无过渡金属方法以及用于这种转化的不同硫和氧源的发展,这些转化提供了更高的效率、选择性和官能团耐受性。同时,对碳杂原子偶联反应的研究现状和发展前景进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信