{"title":"Copper-Mediated C(sp2)-S Coupling: a Strategy for the Preparation of S-Aryl Dithiocarbamates","authors":"Piyushkumar Satani, Sudha Soliya, Bharatkumar Prajapati, Kuldeep Joshi, Subrata Dutta, Togati Naveen","doi":"10.1002/ajoc.202500419","DOIUrl":null,"url":null,"abstract":"<p>We developed an efficient copper-mediated one-pot, three-component reaction for synthesizing <i>S-</i>aryl dithiocarbamates from aliphatic amines, phenylboronic acid, and carbon disulfide. This approach proceeds under mild, ambient conditions without requiring a base or additional additives, significantly reducing reaction time. Using easily accessible starting materials makes the process cost-effective and scalable, yielding high product quantities with minimal complexity. Due to its efficiency, simplicity, and versatility, this method represents a significant advancement in dithiocarbamate synthesis, with promising applications in organic and medicinal chemistry.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500419","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
We developed an efficient copper-mediated one-pot, three-component reaction for synthesizing S-aryl dithiocarbamates from aliphatic amines, phenylboronic acid, and carbon disulfide. This approach proceeds under mild, ambient conditions without requiring a base or additional additives, significantly reducing reaction time. Using easily accessible starting materials makes the process cost-effective and scalable, yielding high product quantities with minimal complexity. Due to its efficiency, simplicity, and versatility, this method represents a significant advancement in dithiocarbamate synthesis, with promising applications in organic and medicinal chemistry.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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