Measurement equivalence of the UDS version 2.0 and 3.0 neuropsychological batteries

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-15 DOI:10.1002/alz.70720

Leslie S. Gaynor, Francesca V. Lopez, Carol A. Van Hulle, Clara Li, Sarinnapha M. Vasunilashorn, Shea J. Andrews, Stephanie M. Simone, Dan M. Mungas

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Abstract

INTRODUCTION

The present study examined the dimensional structure of the neuropsychological test batteries from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) versions 2.0 and 3.0 and measurement equivalence across UDS versions and race/ethnicity groups.

METHODS

There were 49,895 participants included in the present study. The best-fitting model was developed and tested in separate samples. Multiple group confirmatory factor analysis (CFA) evaluated measurement equivalence across UDS versions and race/ethnicity groups.

RESULTS

Results identified a best-fitting four-factor model with residual structure. Multiple group CFA supported partial scalar invariance by UDS version and race/ethnicity group. Regarding race/ethnicity groups, the Language and Attention domains had more non-invariant intercepts, which most affected the White group.

DISCUSSION

A four-factor model effectively summarizes the UDS neuropsychological test batteries across UDS versions and race/ethnicity groups. Crucial differences in measurement parameters must be accounted for in studies using these neuropsychological tests as outcomes.

Highlights

A four-factor model summarizes cognition across Uniform Data Set (UDS) versions and race/ethnicity groups.
Measurement invariance exists across race/ethnicity groups.
Model fit differs between cognitively impaired and unimpaired samples.
Accounting for differences in measurement parameters across groups is essential.
Tailored normative data are crucial for certain UDS tests, including category fluency.

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UDS 2.0和3.0版本神经心理电池的测量等效性

本研究考察了美国国家阿尔茨海默病协调中心（NACC）统一数据集（UDS） 2.0和3.0版本的神经心理测试单元的维度结构，以及UDS版本和种族/民族之间的测量等效性。方法共纳入49895名被试。开发了最佳拟合模型，并在不同的样本中进行了测试。多组验证性因子分析（CFA）评估了UDS版本和种族/民族组的测量等效性。结果确定了具有剩余结构的最佳拟合四因素模型。多组CFA支持UDS版本和种族/族裔组的部分标量不变性。就种族/民族群体而言，语言和注意力领域有更多的非不变拦截，这对白人群体影响最大。一个四因素模型有效地总结了UDS不同版本和种族/民族的UDS神经心理测试。在使用这些神经心理学测试作为结果的研究中，必须考虑测量参数的关键差异。一个四因素模型总结了统一数据集（UDS）版本和种族/民族群体的认知。测量不变性存在于种族/民族群体中。模型拟合在认知受损和未受损样本之间有所不同。考虑各组之间测量参数的差异是至关重要的。量身定制的规范数据对于某些UDS测试至关重要，包括类别流畅性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.