Strophioglandins A–C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.04,13]tridecane core from Strophioblachia glandulosa var. cordifolia

IF 4.9 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2025-09-15 DOI:10.1007/s13659-025-00548-1

Jian-Kai Xia, Lei-Ming Wu, Wei-Ye Wu, Dong Huang, Fang-Yu Yuan, Lei Li, Shu-Qi Wu, Yan-Jiang Zhang, Tao Yuan, Xin Chen, Gui-Hua Tang, Jia-Luo Huang, Sheng Yin

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引用次数: 0

Abstract

Strophioglandins A−C (1−3), three highly rearranged norditerpenoids featuring an unusual tricyclo[6.4.1.0^4,13]tridecane core, were isolated from Strophioblachia glandulosa var. cordifolia. Integrated spectroscopic analyses, X-ray crystallography, and ECD calculations synergistically determined their molecular architectures. Remarkably, all compounds manifested potent anti-inflammatory effects in LPS-activated RAW264.7 cells with IC₅₀ values ranging from 7.83 ± 1.11 to 15.09 ± 1.21 μM. Mechanism study revealed that strophioglandin A (1), the most potent compound, could suppress the expression of multiple inflammatory factors by inhibiting the P38 and Erk1/2 MAPK signaling pathways.

Graphical Abstract

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含有一个不寻常的三环[6.4.1.4.04,13]三烷烃核的高度重排的北二萜类化合物

Strophioglandins A−C（1−3）是三个高度重排的北二萜类化合物，具有罕见的三环[6.4.1.04,13]三烷核心。综合光谱分析、x射线晶体学和ECD计算协同确定了它们的分子结构。值得注意的是，所有化合物对lps激活的RAW264.7细胞均表现出较强的抗炎作用，IC50值在7.83±1.11 ~ 15.09±1.21 μM之间。机制研究发现，其中最有效的化合物strophioglandin A(1)可通过抑制P38和Erk1/2 MAPK信号通路抑制多种炎症因子的表达。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.