Thermosensitive poly(tetrafluoroethylene) films grafted with N-vinylcaprolactam and methyl methacrylate by gamma radiation

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-09-11 DOI:10.1016/j.radphyschem.2025.113310

Elisa Vázquez-Galván, Y. Aylin Esquivel-Lozano, Emilio Bucio

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Abstract

This study presents the radiation-induced grafting of methyl methacrylate (MMA) and N-vinylcaprolactam (NVCL) by two step-method onto poly(tetrafluoroethylene) (PTFE, Teflon®) films. The effects of solvent, monomer concentration, and irradiation dose were studied for the second step: grafting of NVCL onto PTFE films previously modified with MMA (PTFE-g-MMA), to establish the best conditions for the synthesis of (PTFE-g-MMA)-g-NVCL thermo-responsive copolymers. The resulting material was characterized using Fourier Transform Infrared Spectroscopy with Attenuated Total Reflection (FTIR-ATR), Differential Scanning Calorimetry (DSC), and Thermogravimetric Analysis (TGA). Additionally, physicochemical studies were performed, including limit swelling, drop water contact angle, and Lower Critical Solution Temperature (LCST). Finally, the loading and release of norfloxacin was studied for pristine PTFE, MMA-grafted, and (PTFE-g-MMA)-g-NVCL films, the latter being the one that was able to load and release the highest amount of drug, being a new material with potential biomedical applications.

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γ辐射接枝n -乙烯基己内酰胺和甲基丙烯酸甲酯的热敏聚四氟乙烯薄膜

研究了甲基丙烯酸甲酯（MMA）和n-乙烯己内酰胺（NVCL）在聚四氟乙烯（PTFE, Teflon®）薄膜上的辐射诱导接枝。研究了溶剂、单体浓度和辐照剂量对第二步的影响：将NVCL接枝到先前用MMA修饰过的PTFE薄膜上（PTFE-g-MMA），确定了合成(PTFE-g-MMA)-g-NVCL热敏共聚物的最佳条件。利用傅里叶变换红外光谱（FTIR-ATR）、差示扫描量热法（DSC）和热重分析（TGA）对所得材料进行了表征。此外，还进行了物理化学研究，包括极限膨胀、水滴接触角和较低临界溶液温度（LCST）。最后，研究了原始PTFE、mma接枝膜和(PTFE-g- mma)-g-NVCL膜对诺氟沙星的载药量和释放量，发现后者的载药量和释放量最高，是一种具有潜在生物医学应用前景的新材料。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.