Effects of dietary supplementation with cysteamine on growth performance, rumen microflora, and endogenous hormones levels in Hu lambs

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Feed Science and Technology Pub Date : 2025-09-11 DOI:10.1016/j.anifeedsci.2025.116503

Songhua Yang, Tongtong Xie, Fei Li, Fadi Li, Long Guo

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引用次数: 0

Abstract

Cysteamine (CS) is known for its ability to elevate the concentration of growth hormone and thereby promote animal growth. This study was conducted to determine the effects of CS on growth performance, apparent nutrient digestibility, ruminal fermentation and bacterial community, endogenous hormone concentration and the expression of their receptors of Hu lambs during the whole feeding period. Thirty-six healthy male Hu lambs with similar age (75 ± 10 d) and initial body weights (20.3 ± 0.3 kg) were selected and randomly divided into 2 groups, including a CON group and a CS group. The CON group was fed with the basal diet, and the CS group was fed 20 mg/kg BW cysteamine added to the basic diet. The results showed that the addition of CS to the diet had no effects (P > 0.05) on growth performance, slaughter performance, apparent nutrient digestibility, rumen fermentation characteristics, rumen bacterial diversity, growth hormone axis and related hormone receptors of lambs. Furthermore, dietary CS supplementation increased (P ＜ 0.05) hypophysis luteinising hormone concentrations and tended to increase hypophysis growth hormone (P = 0.09) and induced serum testosterone concentrations (P = 0.06). Analysis of rumen bacterial diversity revealed no differences in ACE and Chao1, but the Simpson and Shannon indices were lower in the CS group (P < 0.01), indicating reduced bacterial diversity. Community composition was dominated by Bacteroidetes and Firmicutes, with CS supplementation decreasing the relative abundance of Ruminococcaceae_UCG_014 and Rikenellaceae_RC9_gut_group. Our study demonstrates that supplementation of 20 mg/kg body weight cysteamine did not affect the growth performance, rumen fermentation and nutrient apparent digestibility of Hu lambs under house feeding conditions, but exerts effects on the secretion of reproductive hormones within the hypothalamic-pituitary-gonadal axis.

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饲粮中添加半胱胺对湖羊生长性能、瘤胃菌群及内源激素水平的影响

半胱胺（CS）具有提高生长激素浓度从而促进动物生长的能力。本试验旨在研究CS对整个饲喂期湖羊生长性能、营养物质表观消化率、瘤胃发酵和细菌群落、内源激素浓度及其受体表达的影响。选取年龄（75 ± 10 d）、初始体重（20.3 ± 0.3 kg）相近的健康湖羊羔羊36只，随机分为CON组和CS组。CON组饲喂基础饲粮，CS组在基础饲粮中添加20 mg/kg BW半胱胺。结果表明，饲粮中添加CS对羔羊生长性能、屠宰性能、营养物质表观消化率、瘤胃发酵特性、瘤胃细菌多样性、生长激素轴及相关激素受体无显著影响（P >； 0.05）。此外，饲粮中添加CS增加了垂体促黄体生成素浓度（P < 0.05），并有增加垂体生长激素浓度（P = 0.09）和诱导血清睾酮浓度（P = 0.06）的趋势。瘤胃细菌多样性分析显示，ACE和Chao1无差异，但CS组Simpson和Shannon指数较低（P <； 0.01），表明细菌多样性降低。群落组成以拟杆菌门（Bacteroidetes）和厚壁菌门（Firmicutes）为主，添加CS降低了Ruminococcaceae_UCG_014和Rikenellaceae_RC9_gut_group的相对丰度。本研究表明，在户饲条件下，添加20 mg/kg体重的半胱胺对湖羊的生长性能、瘤胃发酵和营养物质表观消化率没有影响，但对下丘脑-垂体-性腺轴内生殖激素的分泌有影响。

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来源期刊

Animal Feed Science and Technology 农林科学-奶制品与动物科学

CiteScore

6.00

自引率

6.20%

发文量

266

审稿时长

3 months

期刊介绍： Animal Feed Science and Technology is a unique journal publishing scientific papers of international interest focusing on animal feeds and their feeding. Papers describing research on feed for ruminants and non-ruminants, including poultry, horses, companion animals and aquatic animals, are welcome. The journal covers the following areas: Nutritive value of feeds (e.g., assessment, improvement) Methods of conserving and processing feeds that affect their nutritional value Agronomic and climatic factors influencing the nutritive value of feeds Utilization of feeds and the improvement of such Metabolic, production, reproduction and health responses, as well as potential environmental impacts, of diet inputs and feed technologies (e.g., feeds, feed additives, feed components, mycotoxins) Mathematical models relating directly to animal-feed interactions Analytical and experimental methods for feed evaluation Environmental impacts of feed technologies in animal production.